{"created":"2023-05-15T16:31:00.325108+00:00","id":2289,"links":{},"metadata":{"_buckets":{"deposit":"14071f39-5d7a-4ed2-b19e-d65161cf8d35"},"_deposit":{"created_by":2,"id":"2289","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2289"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002289","sets":["35:36"]},"author_link":["10668","10672","10674","10678","10669","10670","10667","10676","10677","10666","10671","10673","10675"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"45963","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency overlaps with malaria endemicity although it predisposes carriers to hemolysis. This fact supports the protection hypothesis against malaria. The aim of this systematic review is to assess the presence and the extent of protective association between G6PD deficiency and malaria. Thirteen databases were searched for papers reporting any G6PD alteration in malaria patients. Twenty-eight of the included 30 studies were eligible for the meta-analysis. Results showed absence of negative association between G6PD deficiency and uncomplicated falciparum malaria (odds ratio (OR), 0.77; 95% confidence interval (CI), 0.59-1.02; p = 0.07). However, this negative association happened in Africa (OR, 0.59; 95% CI, 0.40-0.86; p = 0.007) but not in Asia (OR, 1.24; 95% CI, 0.96-1.61; p = 0.10), and in the heterozygotes (OR, 0.70; 95% CI, 0.57-0.87; p = 0.001) but not the homo/hemizygous (OR, 0.70; 95% CI, 0.46-1.07; p = 0.10). There was no association between G6PD deficiency and total severe malaria (OR, 0.82; 95% CI, 0.61-1.11; p = 0.20). Similarly, there was no association with other malaria species. G6PD deficiency can potentially protect against uncomplicated malaria in African countries, but not severe malaria. Interestingly, this protection was mainly in heterozygous, being x-linked thus related to gender.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 7, 45963; 2017","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Macmillan Publishers Limited,"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep45963","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2017 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mbanefo, Evaristus Chibunna"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ahmed, Ali Mahmoud"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Titouna, Afaf"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Elmaraezy, Ahmed"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Trang, Nguyen Thi Huyen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Phuoc, Long  Nguyen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hoang, Anh  Nguyen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Diem, Nghi  Tran"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"The, Hung  Bui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Van, Hieu  Mai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ky, Anh  Nguyen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huy, Nguyen Tien"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirayama, Kenji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"SciRep7_45963.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep7_45963.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2289/files/SciRep7_45963.pdf"},"version_id":"86eb06cd-fe35-436b-9ae5-a6f332de5ac7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association of glucose-6-phosphate dehydrogenase deficiency and malaria: a systematic review and meta-analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of glucose-6-phosphate dehydrogenase deficiency and malaria: a systematic review and meta-analysis"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-05"},"publish_date":"2017-06-05","publish_status":"0","recid":"2289","relation_version_is_last":true,"title":["Association of glucose-6-phosphate dehydrogenase deficiency and malaria: a systematic review and meta-analysis"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:49:46.384267+00:00"}