{"created":"2023-05-15T16:46:44.919796+00:00","id":23155,"links":{},"metadata":{"_buckets":{"deposit":"fae31c35-99d9-4381-b45c-2e11e8ad98a4"},"_deposit":{"created_by":2,"id":"23155","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"23155"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00023155","sets":["52:56"]},"author_link":["97748","97746","97744","97747","97742","97743","97745","97749","97750","97741"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"95","bibliographicPageStart":"93","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"Journal of Health Science"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the estrogenic activity of a bisphenol A (BPA) metabolite (4-methyl-2,4-bis(p-hydroxyphenyl)-pent-1-ene; MBP) in male medaka (Oryzias latipes) using vitellogenin (Vg, Vg1 and Vg2) as a biomarker. Male d-rR medaka were exposed to various concentrations of estradiol-17β (E2), MBP and BPA for 3 days, and then the serum Vg concentration was measured using specific chemiluminescent immunoassays. The estimated relative estrogenic activities of MBP and BPA compared with E2 (100%) were 1.3-1.4% and 0.00010-0.00023%, respectively. These findings indicated that MBP has about 104-fold higher estrogenic potency than the parent BPA and about 1/50 that of E2 for Vg synthesis in medaka. This is the first study to show that MBP can act as a highly potent estrogen agonist in living organisms.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Health Science v.51(1) p.93-95, 2005","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/jhs.51.93","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.1248/jhs.51.93"}]}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11316464","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13449702","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-5207","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nagae, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiroyama, Ken'Ichirou"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inoue, Mihoka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takao, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohra, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishibashi, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tominaga, Nobuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshihara, Shin'Ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arizono, Koji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"JHS51_93.pdf","filesize":[{"value":"150.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JHS51_93.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/23155/files/JHS51_93.pdf"},"version_id":"ca5f6020-adcd-4837-a3a8-0caf15ff8250"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bisphenol A metabolite","subitem_subject_scheme":"Other"},{"subitem_subject":"estrogenic activity","subitem_subject_scheme":"Other"},{"subitem_subject":"vitellogenin","subitem_subject_scheme":"Other"},{"subitem_subject":"4-methyl-2,4-bis(p-hydroxyphenyl)-pent-1-ene","subitem_subject_scheme":"Other"},{"subitem_subject":"medaka","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Estrogenic Potency of a Bisphenol A Metabolite on Vitellogenin Synthesis in Medaka, Oryzias latipes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Estrogenic Potency of a Bisphenol A Metabolite on Vitellogenin Synthesis in Medaka, Oryzias latipes"}]},"item_type_id":"2","owner":"2","path":["56"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-10-12"},"publish_date":"2007-10-12","publish_status":"0","recid":"23155","relation_version_is_last":true,"title":["Estrogenic Potency of a Bisphenol A Metabolite on Vitellogenin Synthesis in Medaka, Oryzias latipes"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T00:58:45.663596+00:00"}