{"created":"2023-05-15T16:46:45.050723+00:00","id":23158,"links":{},"metadata":{"_buckets":{"deposit":"8cab88c5-1781-47b8-9a55-6d2115a393e7"},"_deposit":{"created_by":2,"id":"23158","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"23158"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00023158","sets":["52:56"]},"author_link":["97763","97759","97766","97764","97761","97765","97762","97760"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"33","bibliographicPageStart":"28","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Journal of Health Science"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this paper, Caenorhabditis elegans (C. elegans) is proposed as a model organism for studying chemical effects over multiple generations. We investigated whether C. elegans responds to vertebrate steroid hormones. We found that estrogenic steroids, especially estradiol (E2), have a cholesterol-like potency in supporting the reproduction of C. elegans. In contrast, testosterone (TS) and diethylstilbestrol (DES) did not display this potency. On the other hand, E2, TS and DES supressed the fecundity rate of C. elegans, when culture carried out with cholesterol. Moreover effect of TS accumulated over generation, in contrast to the other chemicals tested. These data suggested that with convenient biomarkers such as fecundity, C. elegans might be an effective model organism for studying chemical actions, including the disruption of reproduction.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Health Science v.49(1) p.28-33, 2003","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/jhs.49.28","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.1248/jhs.49.28"}]}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11316464","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13449702","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-5207","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tominaga, Nobuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ura, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawaguchi, Tomoaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohra, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsui, Yoshinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iguchi, Taisen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arizono, Koji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"JHS49_28.pdf","filesize":[{"value":"154.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JHS49_28.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/23158/files/JHS49_28.pdf"},"version_id":"4820e05b-5810-47f0-8c5f-976a45bbcd48"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Caenorhabditis elegans","subitem_subject_scheme":"Other"},{"subitem_subject":"reproduction","subitem_subject_scheme":"Other"},{"subitem_subject":"fecundity","subitem_subject_scheme":"Other"},{"subitem_subject":"endocrine disrupting chemical","subitem_subject_scheme":"Other"},{"subitem_subject":"steroid hormone","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Caenorhabditis elegans Responses to Specific Steroid Hormones","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Caenorhabditis elegans Responses to Specific Steroid Hormones"}]},"item_type_id":"2","owner":"2","path":["56"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-10-12"},"publish_date":"2007-10-12","publish_status":"0","recid":"23158","relation_version_is_last":true,"title":["Caenorhabditis elegans Responses to Specific Steroid Hormones"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T00:58:42.961429+00:00"}