@article{oai:nagasaki-u.repo.nii.ac.jp:00023165,
 author = {Kawakami, Shigeru and Horimoto, Tomomi and Nishida, Koyo and Hirayama, Ryu and Mukai, Takahiro and Nakashima, Mikiro and Sasaki, Hitoshi and Sakaeda, Toshiyuki and Nakamura, Junzo},
 issue = {7},
 journal = {Biological & Pharmaceutical Bulletin},
 month = {Jul},
 note = {The present study was undertaken to elucidate the kidney- and site-selective delivery of 5-fluorouracil (5-FU) utilizing the absorption on the kidney surface in rats. An experimental system utilizing a cylindrical diffusion cell attached to the right kidney surface was established. After intravenous administration of 5-FU, the concentration of 5-FU in the right and left kidneys was almost the same and was rapidly eliminated. After right kidney surface application of 5-FU, however, the concentration of 5-FU in the right kidney was significantly higher than in the left kidney and other tissues. The 5-FU concentration in four sites of the right kidney after intravenous administration was almost the same. In contrast, 5-FU was site selectively delivered in the kidney after kidney surface application. The blood concentration of 5-FU was low (<1.7 μg/ml) until 120 min after kidney surface application. The maximum blood concentration of 5-FU after kidney surface application was much lower than after intravenous administration., Biological & Pharmaceutical Bulletin v.25(7) p.928-930, 2002},
 pages = {928--930},
 title = {Kidney- and Site-Selective Delivery of 5-Fluorouracil Utilizing the Absorption on the Kidney Surface in Rats},
 volume = {25},
 year = {2002}
}