{"created":"2023-05-15T16:46:45.659032+00:00","id":23172,"links":{},"metadata":{"_buckets":{"deposit":"07da8754-589a-4e61-a691-eff3341b18ac"},"_deposit":{"created_by":2,"id":"23172","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"23172"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00023172","sets":["73:74"]},"author_link":["97847","97849","97848","97851","97850","97846"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"255","bibliographicPageStart":"251","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Biological & Pharmaceutical Bulletin"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Eighteen main compounds, including four norsesquiterpenoids (1?4) and 14 phenolic compounds (5?18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5?8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biological & Pharmaceutical Bulletin v.27(2) p.251-255, 2004","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"14758047","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.27.251","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.1248/bpb.27.251"}]}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09186158","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-5215","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Ying-Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagao, Tsuneatsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yang, Chong-Ren"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okabe, Hikaru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kouno, Isao"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"BPBul27_251.pdf","filesize":[{"value":"83.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BPBul27_251.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/23172/files/BPBul27_251.pdf"},"version_id":"dd27602f-fca9-43cb-b751-4311def3969b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Phyllanthus emblica","subitem_subject_scheme":"Other"},{"subitem_subject":"Euphorbiaceae","subitem_subject_scheme":"Other"},{"subitem_subject":"antiproliferative activity","subitem_subject_scheme":"Other"},{"subitem_subject":"MK-1 cell","subitem_subject_scheme":"Other"},{"subitem_subject":"HeLa cell","subitem_subject_scheme":"Other"},{"subitem_subject":"B16F10 cell","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antiproliferative Activity of the Main Constituents from Phyllanthus emblica","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antiproliferative Activity of the Main Constituents from Phyllanthus emblica"}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-10-12"},"publish_date":"2007-10-12","publish_status":"0","recid":"23172","relation_version_is_last":true,"title":["Antiproliferative Activity of the Main Constituents from Phyllanthus emblica"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T00:58:04.695356+00:00"}