{"created":"2023-05-15T16:46:46.524477+00:00","id":23192,"links":{},"metadata":{"_buckets":{"deposit":"edf3dd8a-b16f-4839-8b79-2d28cf92f5b2"},"_deposit":{"created_by":2,"id":"23192","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"23192"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00023192","sets":["73:74"]},"author_link":["97958","97952","97955","97956","97957","97954","97953"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"262","bibliographicPageStart":"258","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"Chemical & Pharmaceutical Bulletin"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The association of 10 different tannins and related polyphenols with gramicidin S, a cyclic peptide having a rigid β-turn structure, has been examined using 1H-NMR spectroscopy. In the presence of pentagalloylglucose and epigallocatechin-3-O-gallate, the proton signals due to proline and the adjacent phenylalanine moieties selectively shifted to up field, suggesting a regioselective association with the β-turn structure. The association was also supported by the observation of intermolecular nuclear Overhauser effects between epigallocatechin-3-O-gallate and the peptide. In contrast, ellagitannins, biogenetically derived from pentagalloylglucose, showed small and non-selective chemical shift changes, suggesting that interaction with these tannins is relatively weak. The hydrophobicity of the tannin molecules and the steric hindrance of the interaction site are thought to be important in the association.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Chemical & Pharmaceutical Bulletin v.50(2) p.258-262, 2002","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"11848219","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/cpb.50.258","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.1248/cpb.50.258"}]}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00092363","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-5223","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Ying-Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Betsumiya, Yayoi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kusano, Rie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueda, Toshihisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kouno, Isao"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"CPBul50_258.pdf","filesize":[{"value":"78.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CPBul50_258.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/23192/files/CPBul50_258.pdf"},"version_id":"e0a675e3-bf7e-4d68-8bbf-52511e4dbcec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"polyphenol","subitem_subject_scheme":"Other"},{"subitem_subject":"β-turn","subitem_subject_scheme":"Other"},{"subitem_subject":"hydrophobic","subitem_subject_scheme":"Other"},{"subitem_subject":"tannin","subitem_subject_scheme":"Other"},{"subitem_subject":"peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"epigallocatechin 3-O-gallate","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association of Tannins and Related Polyphenols with the Cyclic Peptide Gramicidin S","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of Tannins and Related Polyphenols with the Cyclic Peptide Gramicidin S"}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-10-12"},"publish_date":"2007-10-12","publish_status":"0","recid":"23192","relation_version_is_last":true,"title":["Association of Tannins and Related Polyphenols with the Cyclic Peptide Gramicidin S"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T00:57:05.759239+00:00"}