{"created":"2023-05-15T16:48:06.255185+00:00","id":25014,"links":{},"metadata":{"_buckets":{"deposit":"f04ebd5d-1df4-4db4-86c3-bb8c781dcb1c"},"_deposit":{"created_by":2,"id":"25014","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"25014"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00025014","sets":["35:1741:1775:1845"]},"author_link":["105792","105793","105789","105791","105790","105788"],"item_3_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Further Histological Study of the Role of Hepatitis B Infection on the Development of Hepatocellular Carcinoma"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1984-09-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"136","bibliographicPageStart":"123","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"熱帯医学 Tropical medicine"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1964年から1980年における長崎大学での剖検例6339例のうち,肝疾患を主病変とする症例953例について,検討した.全剖検例に占める肝疾患の比率は,萎縮性肝硬変(7.7%),肝細胞癌(4.8%)で,同期間における全日本の平均(日本剖検輯報による)の5.2%及び3.5%と比較し高率であり,統計学的に有意差を示した.又,488例の萎縮性肝硬変のうち242例(49.6%)に,肝細胞癌の合併がみられ,一方303例の肝細胞癌のうち242例(78.9%)に萎縮性肝硬変が認められた.上記953例のうち,組織学的に詳細な検討が可能であった652例につき, H. E染色,志方によるオルセイン染色を行い,肝組織型,組織HBs-Agの有無,間質炎症反応の有無, Dysplasiaの有無,肝細胞癌のGrade,及びこれらの相互の関係について検討した.肝組織HBs-Agは,萎縮性肝硬変+肝細胞癌の群では高率で60.6%に陽性であった. 196例の肝細胞癌のうち,非癌部の組織が萎縮性肝硬変でないものは41例でこのうちの14例にHBs-Agが認められた.この14例のうち6例は非癌部の組織が軽度の線維かのみか,又は特に著変を認めないものであり, HBs-Agは直接にoncogenic作用を持つという仮説を支技する所見と思われた.萎縮性肝硬変症例についてLiver cell dysplasiaの有無について検討したが,肝細胞癌の合併の有無により,陽性率に差がみられた.さらに,長与B型の萎縮性肝硬変群では, HBs-Agの陽性率とDysplasiaの出現との間に有意な関係がみられた.","subitem_description_type":"Abstract"},{"subitem_description":"A total of 953 cases of various types of liver diseases were selected for examination from 6339 autopsies performed in Nagasaki University Hospital from 1964 through 1980. The association between HBs-Ag in liver tissue and the histology of the liver was studied using Shikata's orcein staining method. Of the 6339 autopsies performed, 488 cases of atrophic liver cirrhosis (7.7%) and 303 cases of primary hepatocellular carcinoma (4.8%) were identified. These incidences of liver diseases were statistically significantly higher compared with those of national averages of Japan (5.2% and 3.5% respectively). A histological analysis of 953 cases indicated that 242 out of 488 cases of atrophic liver cirrhosis were associated with hepatocellular carcinoma (49.6%) and that 242 out of 303 cases of hepatocellular carcinoma were combined with atrophic liver cirrhosis (78.9%). No HBs-Ag was detected in the tissues of cases of acute liver atrophy or liver cirrhosis with the exception of atrophic liver cirrhosis. HBs-Ag was present in 6 out of 22 cases of subacute hepatitis (27.2%) and in 6 out of 37 chronic hepatitis (16.2%). The highest rate of detectable HBs-Ag was observed in the liver tissues of the subgroup of atrophic liver cirrhosis with hepatocellular carcinoma (60.6%). Among 196 cases of hepatocellular carcinoma examined, HBs-Ag was detected in 14 of those cases which did not exhibit atrophic liver cirrhosis. These results suggest that nepatocellular carcinoma can arise without setting of hepatitis B chronic liver cirrhosis and support the hypothesis that HBs-Ag may be directly oncogenic. Liver cell dysplasia was found in 69 out of 154 cases of atrophic liver cirrhosis with hepatocellular carcinoma (44.8%) and in 22 out of 122 cases of atrophic liver cirrhosis without hapatocellular carcinoma (18.0%). Furthermore, there was a strong correlation between the presence of HBs-Ag in the liver tissue of Nagayo's type B atrophic liver cirrhosis and the existence of cellular dysplasia.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"熱帯医学 Tropical medicine 26(3). p123-136, 1984","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"105791","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Toda, Yumiko"}]},{"nameIdentifiers":[{"nameIdentifier":"105792","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Senba, Masachika"}]},{"nameIdentifiers":[{"nameIdentifier":"105793","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Itakura, Hideyo"}]}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎大学熱帯医学研究所"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00199644","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855643","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00123-P00136"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Institute of Tropical Medicine, Nagasaki University"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"戸田, ゆみ子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"千馬, 正敬"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"板倉, 英世"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"tm26_03_04_t.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"tm26_03_04_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/25014/files/tm26_03_04_t.pdf"},"version_id":"eb3aea8c-55c9-4d15-9e65-e8d262877c35"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肝細胞癌発生におけるB型肝炎ウイルスの役割に関する病理組織学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌発生におけるB型肝炎ウイルスの役割に関する病理組織学的研究"}]},"item_type_id":"3","owner":"2","path":["1845"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-04-26"},"publish_date":"2006-04-26","publish_status":"0","recid":"25014","relation_version_is_last":true,"title":["肝細胞癌発生におけるB型肝炎ウイルスの役割に関する病理組織学的研究"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-15T23:53:49.407560+00:00"}