@article{oai:nagasaki-u.repo.nii.ac.jp:00025021,
 author = {藤原, 真理子 and 范, 育仁 and 小坂, 光男 and Ye, Win},
 issue = {4},
 journal = {熱帯医学 Tropical medicine},
 month = {Dec},
 note = {大腸菌由来のlipopolysaccharide (LPS)を用いて,ウサギの発熱曲線の解折を行った.ウサギに体重1kgあたり0.2μgのLPS pyrogenを耳介皮膚血管から静脈内投与すると,10分から30分の短い潜時ののちに,二峰性の発熱が観察された.ところが,同濃度のpyrogenの側脳室への直接注入では,約1時間の潜時で,直腸温の上昇も1.5℃から2.0℃と,pyrogen静注時に比較すると高い一峰性の発熱が生じた.投与部位の差異による発熱パターンの違いから,LPS pyrogenの作用部位とその働きについて考察を加えた., Fever-curves were compared on response to injection of bacterial pyrogen into conscious rabbits using different routes of administration. Intravenous application of 0.2μg/kg LPS pyrogen to the rabbit was characterized by biphasic fever after a short delay of 10 to 30 minutes. However, monophasic fever developed when same dosage of LPS was administrated into the lateral-ventricular region. Its latency of fever onset was about 60 minutes with rectal temperature elevating by 1.5 to 2.0℃, and these febrile states continued for more than 5 hours. Based on these results, sites of pyrogen action and their underlying mechanisms were discussed in this paper., 熱帯医学 Tropical medicine 26(4). p187-190, 1984},
 pages = {187--190},
 title = {ウサギ静脈内及び側脳室内へのLPS pyrogen投与による発熱曲線の解析},
 volume = {26},
 year = {1984}
}