{"created":"2023-05-15T16:48:06.556710+00:00","id":25021,"links":{},"metadata":{"_buckets":{"deposit":"3f2c76db-ea99-4510-8cb9-db1e86cfa935"},"_deposit":{"created_by":2,"id":"25021","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"25021"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00025021","sets":["35:1741:1775:1846"]},"author_link":["105857","105862","105861","105860","105855","105856","105859","105858"],"item_3_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"An Analysis of Fever-curves due to the Intravenous vs. Intraventricular Administration of LPS Pyrogen in Rabbits"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1984-12-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"190","bibliographicPageStart":"187","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"熱帯医学 Tropical medicine"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大腸菌由来のlipopolysaccharide (LPS)を用いて,ウサギの発熱曲線の解折を行った.ウサギに体重1kgあたり0.2μgのLPS pyrogenを耳介皮膚血管から静脈内投与すると,10分から30分の短い潜時ののちに,二峰性の発熱が観察された.ところが,同濃度のpyrogenの側脳室への直接注入では,約1時間の潜時で,直腸温の上昇も1.5℃から2.0℃と,pyrogen静注時に比較すると高い一峰性の発熱が生じた.投与部位の差異による発熱パターンの違いから,LPS pyrogenの作用部位とその働きについて考察を加えた.","subitem_description_type":"Abstract"},{"subitem_description":"Fever-curves were compared on response to injection of bacterial pyrogen into conscious rabbits using different routes of administration. Intravenous application of 0.2μg/kg LPS pyrogen to the rabbit was characterized by biphasic fever after a short delay of 10 to 30 minutes. However, monophasic fever developed when same dosage of LPS was administrated into the lateral-ventricular region. Its latency of fever onset was about 60 minutes with rectal temperature elevating by 1.5 to 2.0℃, and these febrile states continued for more than 5 hours. Based on these results, sites of pyrogen action and their underlying mechanisms were discussed in this paper.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"熱帯医学 Tropical medicine 26(4). p187-190, 1984","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"105859","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fujiwara, Mariko"}]},{"nameIdentifiers":[{"nameIdentifier":"105860","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fan, Yu-Jen"}]},{"nameIdentifiers":[{"nameIdentifier":"105861","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ye, Win"}]},{"nameIdentifiers":[{"nameIdentifier":"105862","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kosaka, Mitsuo"}]}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎大学熱帯医学研究所"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00199644","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855643","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00187-P00190"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Institute of Tropical Medicine, Nagasaki University"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤原, 真理子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"范, 育仁"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小坂, 光男"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ye, Win"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"tm26_04_06_t.pdf","filesize":[{"value":"345.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"tm26_04_06_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/25021/files/tm26_04_06_t.pdf"},"version_id":"f97f5253-604c-414c-a095-e70010d30312"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ウサギ静脈内及び側脳室内へのLPS pyrogen投与による発熱曲線の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ウサギ静脈内及び側脳室内へのLPS pyrogen投与による発熱曲線の解析"}]},"item_type_id":"3","owner":"2","path":["1846"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-04-26"},"publish_date":"2006-04-26","publish_status":"0","recid":"25021","relation_version_is_last":true,"title":["ウサギ静脈内及び側脳室内へのLPS pyrogen投与による発熱曲線の解析"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-15T23:53:29.631089+00:00"}