@article{oai:nagasaki-u.repo.nii.ac.jp:00025159,
 author = {Matsumoto, Takaaki and Kosaka, Mitsuo and Yamauchi, Masaki and Ohwatari, Nobu and Yang, Guo-Jie and Nakamura, Koichi and Yamashita, Shunichi and Izumi, Motomori and Nagataki, Shigenobu},
 issue = {3},
 journal = {熱帯医学 Tropical medicine},
 month = {Sep},
 note = {Hyperhidrosis with hyperthyroidism and dry skin with hypothyroidism are clinically well-known phenomenon, however, up to now there is no general agreement concerning the effect of thyroid hormone on thermal sweating based on the objectifve quantitative data. In the present study thermal sweating responses in the patients suffering from hyperthyroidism and hypothyroidism were examined by means of capacitance hygrometer-sweat capture capsule method which can determine much finer fluctuation of sweat rate. In environmental control chamber (25℃, 60% rh) local heat load (43℃ water bath, 30 min) was applied on the lower legs to induce thermal sweating. Sweat-onset time after heat load in hyperthyroidism (n=5) and control group (n=9) were 10.6±5.2 and 15.6±5.0 min (Mean±SD), respectively. Total sweat volume induced by 30 min heat load in both group were 66.06±26.24 and 47.95±31.25 mg/capsule, respectively. Increase of oral temperature at sweat-onset time in both group were 0.20±0.16 and 0.10±0.08℃, respectively. In the two patients suffering from hypothyroidism more than a few years no sweat was observed during 30 min heat load. In one case sweat-onset time was 56 min where 0.50℃ rise in oral temperature, and in the other case no sweat was induced finally even though 0.90℃ increase in oral temperature during 51 min heat load. In contrast remarkably short sweat-onset time and large amount of sweat were observed in the two thyroidectomized patients who stopped replacement therapy of triiodothyronine (T3) two weeks ago, although, whose thyroid function (T3, T4, FT4 and TSH) were revealed the same as the value of long-term hypothyroidism group. From the present results, following two suggestions can be drawn; one is thyroid hormone enhances thermal sweating, the others is thyroid hormone action at the intra-cellular level might be changed relatively slow compared to the regulation of thyroid hormone concentration in serum level. Further researches are necessary to clarify the effect of thyroid hormone on thermal sweating and the action site of thyroid hormone on sweating mechanism., 熱帯医学 Tropical medicine 30(3). p225-231, 1988},
 pages = {225--231},
 title = {Effect of Thyroid Hormone on Thermal Sweating},
 volume = {30},
 year = {1988}
}