{"created":"2023-05-15T16:48:21.351280+00:00","id":25357,"links":{},"metadata":{"_buckets":{"deposit":"f6a358ac-fdc7-49a6-9c9d-9ccfee9d5cae"},"_deposit":{"created_by":2,"id":"25357","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"25357"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00025357","sets":["35:1741:1775:1893"]},"author_link":["107602","107597","107603","107600","107601","107605","107604","107598","107599"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-03-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3/4","bibliographicPageEnd":"99","bibliographicPageStart":"91","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"熱帯医学 Tropical medicine"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The adjuvant activity of liposomes coated with mannan-cholesterol was studied in mice. Ovalbumin (OVA) was reconstituted into liposomes as a model antigen. The adjuvant activity was assessed by the following two immunological responses: delayed-type hypersensitivity (DTH) footpad swelling responses and in vitro release of interferon-γ and interleukin-4 by regional lymph node cells. First, we studied dose effects on DTH responses of total lipid, mannan-cholesterol and OVA used for liposomes. The minimal doses per mouse required for the induction of optimal responses were as follows; 1μg of OVA, 10μg of mannan-cholesterol and 336μg of total lipid. Second, immunological and histopathological studies showed the following two points: 1) mannan-coated liposomes induced a tuberculintype DTH response while non-coated liposomes elicited a Jones-Mote reaction, and 2) mannan-coated liposomes induced obvious microabscesses but non-coated liposome did not. Third, the inoculation of mannan-coated liposomes rendered the regional lymph node cells to release a large amount of interferon-γ with little IL-4 against OVA while non-coated lipo-some released neither of the lymphokines. These results indicated that mannan-coated lipo-somes are a potent adjuvant to induce type 1 helper T cells but have a disadvantage to form microabscesses at the inoculation sites.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"熱帯医学 Tropical medicine 38(3/4). p91-99, 1997","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎大学熱帯医学研究所"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00199644","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855643","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00091-P00099"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Institute of Tropical Medicine, Nagasaki University"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Skikata, Kohdo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohishi, Kazue"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawai, Hiromi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukasawa, Masashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakakibara, Ryuzo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishiguro, Masatsune"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itakura, Hideyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatanaka, Masakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugimoto, Masanobu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"tm38_03_02_t.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"tm38_03_02_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/25357/files/tm38_03_02_t.pdf"},"version_id":"0ca82778-b5a0-4268-9303-21c04acb5116"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunopathological Characterization of liposome Adjuvant Coated with Mannan","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunopathological Characterization of liposome Adjuvant Coated with Mannan"}]},"item_type_id":"3","owner":"2","path":["1893"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-04-26"},"publish_date":"2006-04-26","publish_status":"0","recid":"25357","relation_version_is_last":true,"title":["Immunopathological Characterization of liposome Adjuvant Coated with Mannan"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-15T23:39:13.477354+00:00"}