{"created":"2023-05-15T16:48:22.216865+00:00","id":25377,"links":{},"metadata":{"_buckets":{"deposit":"f602113a-84a8-4c53-861f-bd147dfb5017"},"_deposit":{"created_by":2,"id":"25377","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"25377"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00025377","sets":["35:1741:1775:1897"]},"author_link":["107680","107679"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-09-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"熱帯医学 Tropical medicine"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Easy access to chloroquine (CQ) in many developing countries can result to intake of inappropriate doses. This study was therefore conducted to evaluate the acute effects of high doses of CQ on hematological parameters and plasma Na+and K+ concentrations. To do this, Swiss albino rats were administered incremental doses of CQ intraperitoneally at dose rates ranging between 0.5 to 8mg/kg b.wt. Two hours later, blood samples were taken and analysed. 8mg/kg b.wt of CQ induced significant decrease in red blood cells (RBC), hemoglobin (Hb) and significant increase in mean corpuscular volume (MCV). There was a significant increase in white blood cell count at all dose levels. Packed cell volume (PCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were not affected by all dose ranges. There was significant increase in plasma Na+ and K+ by dose rates of 4 and 8 mg/kg but not by lower doses. These data indicate that most CQ induced toxicities on the formed elements of blood occurs at doses greater than 4 times the standard therapeutic dose in rats.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"熱帯医学 Tropical medicine 40(1). p1-7, 1998","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎大学熱帯医学研究所"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00199644","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855643","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"P00001-P00007"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Institute of Tropical Medicine, Nagasaki University"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Othman, Timothy"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arowolo, R. O. A."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-24"}],"displaytype":"detail","filename":"tm40_01_01_t.pdf","filesize":[{"value":"558.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"tm40_01_01_t.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/25377/files/tm40_01_01_t.pdf"},"version_id":"7f9f1f1b-2635-4f97-ac98-bbbe22823f96"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Incremental Doses of Chloroquine Phosphate on the Formed Elements of Blood.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Incremental Doses of Chloroquine Phosphate on the Formed Elements of Blood."}]},"item_type_id":"3","owner":"2","path":["1897"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-04-26"},"publish_date":"2006-04-26","publish_status":"0","recid":"25377","relation_version_is_last":true,"title":["Effects of Incremental Doses of Chloroquine Phosphate on the Formed Elements of Blood."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-15T23:38:13.791470+00:00"}