@article{oai:nagasaki-u.repo.nii.ac.jp:00002547,
 author = {Udo, Emiko and Furusato, Bungo and Sakai, Kazuko and Prentice, Leah M and Tanaka, Tomonori and Kitamura, Yuka and Tsuchiya, Tomoshi and Yamasaki, Naoya and Nagayasu, Takeshi and Nishio, Kazuto and Fukuoka, Junya},
 journal = {Diagnostic Pathology},
 month = {Aug},
 note = {Background: Ciliated muconodular papillary tumors (CMPTs) are newly recognized rare peripheral lung nodules that are histologically characterized by ciliated columnar, goblet, and basal cells. Although recent studies have shown that CMPTs constitute a neoplastic disease, the complete histogenesis of CMPTs is not fully understood and molecular data are limited. Methods: We reviewed four cases of CMPT and performed immunohistochemical and genomic analyses to establish CMPT profiles. Results: All cases were positive for hepatocyte nuclear factor-4α and mucin 5B and negative for programmed death ligand 1 expression, as determined by immunohistochemistry. The genetic analysis revealed three pathogenic mutations (BRAF V600E, AKT1 E17K, and KRAS G12D), with the KRAS mutation reported here for the first time. Conclusion: Histological and genetic profiles indicate that CMPTs are likely neoplastic and exhibit features similar to mucinous adenocarcinoma. This suggests that some CMPTs may be a precursor lesion of mucinous adenocarcinoma., Diagnostic Pathology, 12, 62; 2017},
 title = {Ciliated muconodular papillary tumors of the lung with KRAS/BRAF/AKT1 mutation},
 volume = {12},
 year = {2017}
}