@article{oai:nagasaki-u.repo.nii.ac.jp:00002564,
 author = {Shimizu, Yuji and Sato, Shimpei and Koyamatsu, Jun and Yamanashi, Hirotomo and Nagayoshi, Mako and Kadota, Koichiro and Kawashiri, Shin-Ya and Maeda, Takahiro},
 journal = {Journal of Physiological Anthropology},
 month = {Jun},
 note = {Background: Although high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor. Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension. Methods: To investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60?69 years who participated in general health checkup. Results: HDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. Known cardiovascular risk factors adjusted odds (ORs) and 95% confidence intervals (CIs) of hypertension for increments of one standard deviation (SD) in HDL (13.8 mg/dL) were 1.44 (1.06, 1.96) for subjects with a high level of circulating CD34-positive cells and 0.87 (0.63, 1.19) for subjects with low circulating CD34-positive cells. We also revealed a significant association between HDL level and CD34-positive cell level on hypertension, with fully adjusted p values for the effect of this interaction on hypertension at 0.022. Conclusions: Independent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells., Journal of Physiological Anthropology, 36, 26; 2017},
 title = {Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels},
 volume = {36},
 year = {2017}
}