{"created":"2023-05-15T16:31:12.381944+00:00","id":2564,"links":{},"metadata":{"_buckets":{"deposit":"371285e9-60e4-4a60-b39e-ad3c34699107"},"_deposit":{"created_by":2,"id":"2564","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2564"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002564","sets":["10:11"]},"author_link":["11951","11950","11946","11949","11948","11945","11947","11944"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"26","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Journal of Physiological Anthropology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Although high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor. Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension. Methods: To investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60?69 years who participated in general health checkup. Results: HDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. Known cardiovascular risk factors adjusted odds (ORs) and 95% confidence intervals (CIs) of hypertension for increments of one standard deviation (SD) in HDL (13.8 mg/dL) were 1.44 (1.06, 1.96) for subjects with a high level of circulating CD34-positive cells and 0.87 (0.63, 1.19) for subjects with low circulating CD34-positive cells. We also revealed a significant association between HDL level and CD34-positive cell level on hypertension, with fully adjusted p values for the effect of this interaction on hypertension at 0.022. Conclusions: Independent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Physiological Anthropology, 36, 26; 2017","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本生理人類学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s40101-017-0143-9","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"18806805","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Japan Society of Physiological Anthropology"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shimpei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koyamatsu, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamanashi, Hirotomo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagayoshi, Mako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadota, Koichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shin-Ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Takahiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"JPA36_26.pdf","filesize":[{"value":"411.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JPA36_26.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2564/files/JPA36_26.pdf"},"version_id":"043c89cd-eb00-41c7-86fe-f4188bb1c0f4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HDL-cholesterol","subitem_subject_scheme":"Other"},{"subitem_subject":"Circulating CD34-positive cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypertension","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-26"},"publish_date":"2017-09-26","publish_status":"0","recid":"2564","relation_version_is_last":true,"title":["Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:44:15.668221+00:00"}