{"created":"2023-05-15T16:31:15.160604+00:00","id":2615,"links":{},"metadata":{"_buckets":{"deposit":"0e406efd-68dc-45cf-b9c8-aafe197999f6"},"_deposit":{"created_by":2,"id":"2615","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2615"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002615","sets":["29:30"]},"author_link":["12029","12032","12031","12028","12034","12030","12033","12035"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"14","bibliographicPageEnd":"1415","bibliographicPageStart":"1408","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"The Prostate"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The effects of neoadjuvant hormonal therapy (NHT) on pathological features and lymphangiogenesis in patients with prostate cancer (PCa) for each pre-operative risk classification are unclear. \nMethods: To clarify the anti-cancer effects of NHT, we investigated 153 patients (non-NHT group?=?80 and NHT group?=?73) who underwent radical prostatectomy (RP) in Nagasaki University Hospital. Lymph vessel density and area (evaluated by D2-40-positive vessels), vascular endothelial growth factor (VEGF)-C and VEGF-D expressions, and biochemical recurrence (BCR)-free survival were compared between these two groups for each D'Amico risk classification (low?=?33, intermediate?=?58, high?=?62 patients). Results: In low-risk PCa patients, the risks of lymph vessel invasion and BCR were significantly higher in the NHT group than in the non-NHT group (P?=?0.040 and 0.022, respectively). Such significant difference was not seen in the intermediate- or high-risk PCa groups. Lymph vessel density of the peri-tumoral and intra-tumoral areas and the lymph vessel area were significantly higher (P?<?0.001) in the NHT group than in the non-NHT group in low-risk PCa. In regard to the expression of VEGF-C or VEGF-D, significant difference was not detected in low-risk PCa. Conclusions: NHT stimulated cancer cell progression and BCR via up-regulation of lymphangiogenesis-related parameters in patients with low-risk PCa. Although VEGF-C and VEGF-D expressions were not changed by NHT, lymph vessel density and area were increased in low-risk PCa patients. We suggest that NHT for patients with low-risk PCa may have a high risk for BCR after RP.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"The Prostate, 77(14), pp.1408-1415; 2017","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley Periodicals, Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/pros.23402","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2017 The Authors. The Prostate Published by Wiley Periodicals, Inc."},{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"02704137","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyata, Yasuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Yuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasuda, Takuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohba, Kojiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furusato, Bungo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuoka, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Hideki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"Pros77_1408.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Pros77_1408.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2615/files/Pros77_1408.pdf"},"version_id":"73b5ed7b-ac54-4cf9-b928-ac4fd6c8bd4c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"biochemical recurrence","subitem_subject_scheme":"Other"},{"subitem_subject":"lymphangiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"neoadjuvant hormonal therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"prostate cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"risk classification","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neoadjuvant hormonal therapy for low-risk prostate cancer induces biochemical recurrence after radical prostatectomy via increased lymphangiogenesis-related parameters","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neoadjuvant hormonal therapy for low-risk prostate cancer induces biochemical recurrence after radical prostatectomy via increased lymphangiogenesis-related parameters"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-11"},"publish_date":"2017-10-11","publish_status":"0","recid":"2615","relation_version_is_last":true,"title":["Neoadjuvant hormonal therapy for low-risk prostate cancer induces biochemical recurrence after radical prostatectomy via increased lymphangiogenesis-related parameters"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:44:01.295003+00:00"}