@article{oai:nagasaki-u.repo.nii.ac.jp:00026269,
 author = {Tabuchi, Maiko and Minami, Hitomi and Akazawa, Yuko and Ashida, Miwa and Hara, Toshihide and Ichinose, Kunihiro and Kitayama, Moto and Hashiguchi, Keiichi and Matsushima, Kayoko and Yamaguchi, Naoyuki and Takeshima, Fuminao and Kondo, Hisayoshi and Kawakami, Atsushi and Nakao, Kazuhiko},
 issue = {2},
 journal = {Biomedical Reports},
 month = {Dec},
 note = {Gastroesophageal reflux disease (GERD) in systemic sclerosis (SSc) can significantly reduce a patient's quality of life. GERD in SSc is occasionally resistant to conventional anti-acid treatment. Vonoprazan is an H+/K+-ATPase blocker that is approved in Japan for treatment of GERD. The aim of the present study was to evaluate the efficacy of vonoprazan in SSc-related GERD. The frequency scale for symptoms of GERD (FSSG) scores were collected before and after vono-prazan treatment in 15 SSc patients with GERD. Additionally, endoscopic esophagogastroduodenoscopy was performed in select patients. Conventional proton pump 
inhibitors or hista-mine-2 receptor antagonists had been previously administered in 93% (14/15) of the patients. Although the baseline esophago-gastroduodenoscopy examination did not show severe erosion in the majority of patients,the mean total FSSG score before vonoprazan treatment was notably high (25.2±10.7) compared to a normal score of <8. After vonoprazan treatment, the FSSG score decreased to 9.6±7.0. The mean improvement rate of the total FSSG, acid reflux and dysmotility scores were 60.8±21.2% (P=0.0004), 67.3±24.8% (P<0.0001) and 55.4±26.0% (P=0.0022), respectively.These results suggest that vonoprazan may be a potentially effective treatment for GERD in patients with SSc., Biomedical Reports, 14(2),  pp.1-8; 2020},
 pages = {1--8},
 title = {Use of vonoprazan for management of systemic sclerosis‑related gastroesophageal reflux disease},
 volume = {14},
 year = {2020}
}