{"created":"2023-05-15T16:49:00.954958+00:00","id":26275,"links":{},"metadata":{"_buckets":{"deposit":"b7d18822-73ab-4f1b-8c4a-e9331a5528f4"},"_deposit":{"created_by":6,"id":"26275","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26275"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026275","sets":["10:11"]},"author_link":["112308","112313","112303","112314","112302","112305","112304","112318","112310","112315","112316","112320","112322","112321","112307","112312","112317","112309","112319","112311","112306"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-11-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"115770","bibliographicVolumeNumber":"144","bibliographic_titles":[{"bibliographic_title":"Bone"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To investigate the effects of sequential therapy with monthly intravenous ibandronate on bone mineral density (BMD) and microstructure in patients with primary osteoporosis who received teriparatide treatment. Methods: Sixty-six patients with primary osteoporosis who had undergone teriparatide treatment for more than 12 months (mean 18.6 months) received sequential therapy with 1 mg/month intravenous ibandronate for 12 months. The patients were evaluated using dual-energy X-ray absorptiometry (DXA), quantitative ultrasound, bone turnover markers, and high-resolution peripheral quantitative computed tomography (HR-pQCT) at baseline and 6 and 12 months after beginning administration. Results: At 12 months after beginning sequential therapy,the bone resorption marker, tartrate-resistant acid phosphatase-5b, decreased by 39.5%, with 82.3% of the patients exhibiting levels within the normal limit. DXA revealed that the BMD of the lumbar spine increased by 3.2%, with 79.0% of the patients exhibiting a response, and 40.3% experiencing an increase in BMD over 5%. HR-pQCT revealed that the cortical thickness of the distal tibia was increased by 2.6%. The cortical area increased by 2.5%, and the buckling ratio (an index of cortical instability) decreased by 2.5%. Most parameters of the trabecular bone showed no significant changes. These changes in the cortical bone were observed in both the distal radius and tibia and appeared beginning 6 months after treatment initiation. Conclusions: Sequential therapy with monthly intravenous ibandronate increased the BMD and improved the cortical bone microstructure of osteoporotic patients who had undergone teriparatide treatment.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Bone, 144, art.no.115770; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bone.2020.115770","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"87563282","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chiba, Ko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Shuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoda, Itaru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Era, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokota, Kazuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okazaki, Narihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Shingo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Isobe, Yusaku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Satsuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tashiro, Shigeki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Sawako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morimoto, Shimpei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shuntaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsukazaki, Tomoo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Enomoto, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yabe, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yonekura, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Masako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osaki, Makoto"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-01-26"}],"displaytype":"detail","filename":"Bone144_115770.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Bone144_115770.pdf ","url":"https://nagasaki-u.repo.nii.ac.jp/record/26275/files/Bone144_115770.pdf"},"version_id":"1d34c03c-2951-434a-bb56-add063fa1314"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bone microstructure","subitem_subject_scheme":"Other"},{"subitem_subject":"High-resolution peripheral quantitative CT (HR-pQCT)","subitem_subject_scheme":"Other"},{"subitem_subject":"Ibandronate","subitem_subject_scheme":"Other"},{"subitem_subject":"Monthly intravenous ibandronate","subitem_subject_scheme":"Other"},{"subitem_subject":"Sequential therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"Teriparatide","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of monthly intravenous ibandronate on bone mineral density and microstructure in patients with primary osteoporosis after teriparatide treatment: The MONUMENT study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of monthly intravenous ibandronate on bone mineral density and microstructure in patients with primary osteoporosis after teriparatide treatment: The MONUMENT study"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-26"},"publish_date":"2021-01-26","publish_status":"0","recid":"26275","relation_version_is_last":true,"title":["Effects of monthly intravenous ibandronate on bone mineral density and microstructure in patients with primary osteoporosis after teriparatide treatment: The MONUMENT study"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T22:55:22.739905+00:00"}