{"created":"2023-05-15T16:49:01.084060+00:00","id":26278,"links":{},"metadata":{"_buckets":{"deposit":"1b107c3f-1b6f-4d02-a1a9-fa63db975f44"},"_deposit":{"created_by":6,"id":"26278","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26278"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026278","sets":["12:13"]},"author_link":["112346","112345","112348","112347","112349","112344"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"106629","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Data in Brief"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The dataset presented herein is related to a previous research article titled “Mitochondrial Complex III in Larval Stage of Echinococcus multilocularis as a Potential Chemotherapeutic Target and in vivo Efficacy of Atovaquone Against Primary Hydatid Cysts” [1]. In this report, data were collected by screening drugs for echinococcosis. We investigated the inhibitory activities of artemisinin and pyrvinium pamoate against the mitochondrial respiratory enzymes in E. multilocularis protoscoleces. Artemisinin did not inhibit mitochondrial complexes I, II, and III. However, pyrvinium pamoate inhibited complex I at 11 μM,although complexes II and III were not inhibited. In the culture assay, E. multilocularis protoscoleces were treated with atovaquone (ATV), rotenone, praziquantel, artemisinin, and pyrvinium pamoate at a final concentration of 50 µM in different culture media. The viability of protoscoleces was compared under aerobic and anaerobic conditions via culture experiments. The survival days of E. multilocularis protoscoleces were evaluated in the drug-treated group compared with those in the non-treated group. The results of these culture assays revealed that praziquantel and artemisinin did not eliminate the protoscoleces under both aerobic and anaerobic conditions. However, a stronger elimination ability was observed with the co-administration of praziquantel or artemisinin with ATV than with ATV alone under aerobic conditions. Pyrvinium pamoate completely killed protoscoleces at 5 and 7 days under aerobic and anaerobic conditions, respectively. Pyrvinium pamoate behaved identically to rotenone, the complex I inhibitor, in the culture treatment assay.The data serve as a reference for the development of novel anti-echinococcal drugs.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Data in Brief, 34, art.no.106629; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.dib.2020.106629","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"23523409","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Enkai, Shigehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kouguchi, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inaoka, Daniel Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Irie, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yagi, Kinpei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kita, Kiyoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-01-26"}],"displaytype":"detail","filename":"DB34_106629.pdf","filesize":[{"value":"361.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DB34_106629.pdf ","url":"https://nagasaki-u.repo.nii.ac.jp/record/26278/files/DB34_106629.pdf"},"version_id":"0d18d733-3246-481b-b846-7a05f86f0589"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Artemisinin","subitem_subject_scheme":"Other"},{"subitem_subject":"Atovaquone","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug target","subitem_subject_scheme":"Other"},{"subitem_subject":"Echinococcosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Echinococcus multilocularis","subitem_subject_scheme":"Other"},{"subitem_subject":"Mitochondria","subitem_subject_scheme":"Other"},{"subitem_subject":"Pyrvinium pamoate","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of the anti-parasitic compounds pyrvinium pamoate and artemisinin in enzymatic and culture assays: Data on the search for new anti-echinococcal drugs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of the anti-parasitic compounds pyrvinium pamoate and artemisinin in enzymatic and culture assays: Data on the search for new anti-echinococcal drugs"}]},"item_type_id":"2","owner":"6","path":["13"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-26"},"publish_date":"2021-01-26","publish_status":"0","recid":"26278","relation_version_is_last":true,"title":["Effect of the anti-parasitic compounds pyrvinium pamoate and artemisinin in enzymatic and culture assays: Data on the search for new anti-echinococcal drugs"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T22:55:20.713757+00:00"}