{"created":"2023-05-15T16:49:02.522268+00:00","id":26313,"links":{},"metadata":{"_buckets":{"deposit":"305d5b3b-3fe3-43b5-9508-495589584233"},"_deposit":{"created_by":6,"id":"26313","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26313"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026313","sets":["6:7"]},"author_link":["117075","117074","117076","117078","117070","117072","117077","117071","117069","117073","117068"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"379","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Nutrients"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Astaxanthin (AX) is a carotenoid that exerts potent antioxidant activity and acts in the lipid bilayer. This study aimed to investigate the effects of AX on muscle-atrophy-mediated disturbance of mitochondria, which have a lipid bilayer. Tail suspension was used to establish a muscleatrophied mouse model. AX diet fed to tail-suspension mice prevented loss of muscle weight, inhibited the decrease of myofiber size, and restrained the increase of hydrogen peroxide (H2O2) production in the soleus muscle. Additionally, AX improved downregulation of mitochondrial respiratory chain complexes I and III in the soleus muscle after tail suspension. Meanwhile, AX promoted mitochondrial biogenesis by upregulating the expressions of adenosine 5'-monophosphate-activated protein kinase (AMPK) α-1, peroxisome proliferator-activated receptor (PPAR)-γ, and creatine kinase in mitochondrial (Ckmt) 2 in the soleus muscle of tail-suspension mice. To confirm the AX phenotype in the soleus muscle, we examined its effects on mitochondria using Sol8 myotubes derived from the soleus muscle. We found that AX was preferentially detected in the mitochondrial fraction; it significantly suppressed mitochondrial reactive oxygen species (ROS) production in Sol8 myotubes. Moreover, AX inhibited the activation of caspase 3 via inhibiting the release of cytochrome c into the cytosol in antimycin A-treated Sol8 myotubes. These results suggested that AX protected the functional stability of mitochondria, alleviated mitochondrial oxidative stress and mitochondriamediated apoptosis, and thus, prevented muscle atrophy.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Nutrients, 13(2), art.no.379; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/nu13020379","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms  andconditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-6643","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sun, Luchuanyang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyaji, Nobuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yang, Min"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mills, Edward M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taniyama, Shigeto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchida, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nikawa, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Jifeng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shi, Jie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tachibana, Katsuyasu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirasaka, Katsuya"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-19"}],"displaytype":"detail","filename":"Nutrients13_379.pdf","filesize":[{"value":"3.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Nutrients13_379.pdf ","url":"https://nagasaki-u.repo.nii.ac.jp/record/26313/files/Nutrients13_379.pdf"},"version_id":"c375e0d3-64b0-491c-8d6f-aea5b27a9a90"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Astaxanthin","subitem_subject_scheme":"Other"},{"subitem_subject":"Mitochondria","subitem_subject_scheme":"Other"},{"subitem_subject":"Muscle atrophy","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative stress","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Astaxanthin Prevents Atrophy in Slow Muscle Fibers by Inhibiting Mitochondrial Reactive Oxygen Species via a Mitochondria-Mediated Apoptosis Pathway","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Astaxanthin Prevents Atrophy in Slow Muscle Fibers by Inhibiting Mitochondrial Reactive Oxygen Species via a Mitochondria-Mediated Apoptosis Pathway"}]},"item_type_id":"2","owner":"6","path":["7"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-02-19"},"publish_date":"2021-02-19","publish_status":"0","recid":"26313","relation_version_is_last":true,"title":["Astaxanthin Prevents Atrophy in Slow Muscle Fibers by Inhibiting Mitochondrial Reactive Oxygen Species via a Mitochondria-Mediated Apoptosis Pathway"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:33:13.158872+00:00"}