{"created":"2023-05-15T16:49:03.087932+00:00","id":26327,"links":{},"metadata":{"_buckets":{"deposit":"d17bc49f-8738-4c2e-8cce-84482c3fec64"},"_deposit":{"created_by":6,"id":"26327","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26327"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026327","sets":["25:26"]},"author_link":["117202","117205","117204","117203","117206"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"251","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Oncology Letters"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dipyridamole, a traditional anti-platelet drug, has been reported to inhibit the proliferation of cancer cells. The present study aimed to investigate the possibility of dipyridamole as an adjuvant of chemotherapy by enhancing the cytotoxicity of an anti-cancer drug. The cytotoxicity of colorectal cancer cells (HCT-8), CD133+/CD44+ stem-like subpopulation of HCT-8 cells and lymphoma cells (U937) to dipyridamole and/or doxorubicin was evaluated using MTT proliferation and colony forming assays. The expression levels of phosphorylated cAMP-regulatory element-binding protein (pCREB) and poly(ADP-ribose) polymerase-1 (PARP-1) in cells were analyzed via western blotting and immunofluores- cence. The present study reported controversial data regarding the anti-cancer effect of dipyridamole. Dipyridamole increased, rather than inhibited, the proliferation of HCT-8 and U937 cells in a dose-dependent manner. Furthermore, it was found that dipyridamole significantly increased the expression levels of pCREB and PARP-1. However, the combined usage of dipyridamole significantly enhanced the cytotoxicity of doxorubicin to HCT-8 cells at particular doses. Based on the current findings, dipyridamole likely induces the phosphoryla- tion of CREB to promote the proliferation of cancer cells, but may enhance the cytotoxicity of anti-cancer drugs at particular doses.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Oncology Letters, 21(4), art.no.251; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/ol.2021.12512","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Abdelghany et al. This is an open access article distributed under the terms of Creative Commons Attribution License."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1792-1074","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Abdelghany, Lina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"El-Μahdy, Nageh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawabata, Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Tao-Sheng"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-02"}],"displaytype":"detail","filename":"OncLet21_251.pdf","filesize":[{"value":"4.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"OncLet21_251.pdf ","url":"https://nagasaki-u.repo.nii.ac.jp/record/26327/files/OncLet21_251.pdf"},"version_id":"94e11ce1-c8ca-45aa-b6c2-1798472e0a58"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Dipyridamole","subitem_subject_scheme":"Other"},{"subitem_subject":"Doxorubicin","subitem_subject_scheme":"Other"},{"subitem_subject":"Human colorectal cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Stem cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation"}]},"item_type_id":"2","owner":"6","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-02"},"publish_date":"2021-03-02","publish_status":"0","recid":"26327","relation_version_is_last":true,"title":["Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:28:47.090442+00:00"}