@article{oai:nagasaki-u.repo.nii.ac.jp:00026332,
 author = {Seto, Makiko and Fukushima, Naomi and Yuasa, Takayuki and Nakao, Yoko and Ichinose, Katsuhiro and Tomita, Itsuro and Satoh, Hideyo and Satoh, Akira and Ochi, Makoto and Tsujihata, Mitsuhiro},
 issue = {3},
 journal = {Acta medica Nagasakiensia},
 month = {Feb},
 note = {Purpose: Our aim was to re-evaluate the usefulness of perfusion single-photon emission computed tomography (SPECT) for the diagnosis of AD and DLB.
Methods: A total of 1,232 patients, including 180 cognitively normal subjects (NSs), 148 patients with amnestic mild cognitive impairment (aMCI), 802 patients with AD and 102 patients with dementia with Lewy bodies (DLB) were enrolled. A voxelbased
stereotactic extraction estimation analysis was used to assess hypoperfusion areas using the cut-off value of 20% for the “extent %” and >2 hypoperfused lesions.
Results: The top 10 areas with hypoperfusion in AD were the angular gyrus, supramarginal gyrus, precuneus, superior occipital gyrus, inferior parietal lobule, middle temporal gyrus, superior parietal lobule, inferior temporal gyrus, superior 
temporal gyrus. and posterior cingulate, while DLB had 6 areas in common with AD. The respective sensitivity and specificity for differentiating AD from NSs were 84.2% and 78.9% for 50-59 years old, and 91.8% and 70.0% for 60-69 years old, but
those values decreased from 70 years old. The respective sensitivity and specificity in DLB patients were 100% and 75.6% for 50-69 years old, 84.6% and 70.1% for 70-79 years old and 81.4% and 77.1% for 80-89 years old. In aMCI patients, the 1-year change in the MMSE scores was -2.38±2.02 (n=16) in patients with abnormal SPECT images and -0.67±1.81 (n=18) in those with normal SPECT images (P<0.02).
Conclusions: Our study confirms that perfusion SPECT is still a valid alternative for the diagnosis of AD and DLB when fluorodeoxyglucose-PET is unavailable., Acta medica Nagasakiensia, 64(3), pp.91-100; 2021},
 pages = {91--100},
 title = {Reappraisal of the Cerebral Blood Flow Measured Using 123I-I-iodoamphetamine Single-photon Emission Computed Tomography in Normal Subjects and Patients with Alzheimer’s Disease and Dementia with Lewy Bodies},
 volume = {64},
 year = {2021}
}