{"created":"2023-05-15T16:49:03.875136+00:00","id":26346,"links":{},"metadata":{"_buckets":{"deposit":"1bbed5d3-4e72-49e3-b8c6-fd9bfbb0a008"},"_deposit":{"created_by":6,"id":"26346","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26346"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026346","sets":["8:9"]},"author_link":["117359","117356","117360","117357","117361","117355","117358"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"266","bibliographicPageStart":"262","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Journal of Infection and Chemotherapy"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, we investigated all Clostridioides difficile strains isolated from stool samples in Nagasaki University Hospital between January 2012 and December 2014. Toxin genes (tcdA, tcdB and cdtA/cdtB) were analyzed for multiplex PCR in a total of 213 strains. In the toxin gene-positive strain, PCR ribotyping was conducted using capillary gel electrophoresis-based PCR and the Webribo database. Patients’ backgrounds were analyzed by departments, disorders, antimicrobials, and clinical dates. The positive rates of tcdA, tcdB, and cdtA/cdtB genes were 62.9%, 63.4%, and 2.8%, respectively. The most frequent PCR ribotype was 047 (14.1%), followed by 014/0 (11.1%) and 002/0 (8.2%). In univariate analysis, the risk factors for the detection of toxin gene-positive strains in patients were older age (p = 0.0036), over ≥ 65 years old (p = 0.0175), the patients hospitalized at Department of Digestive Surgery (P = 0.0059), higher CRP level (P = 0.0395), and lower albumin level (p = 0.0014). In the multivariate analysis, the risk factor for detection of toxin gene-positive strains was the patients hospitalized at Department of Digestive Surgery (OR; 4.62, 95% CI; 1.18–18.0, p = 0.0274). In this study, the percentage of toxin gene-positive and cdtA/cdtB gene-positive strains was almost the same as that reported in previous studies, but the ribotype was different. In addition, we revealed that the risk factor associated with the detection of toxin gene-positive strains was the patients hospitalized at Department of digestive surgery.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Infection and Chemotherapy, 25(4), pp.262-266; 2019","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jiac.2018.12.004","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341321X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okada, Yuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaku, Norihito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kosai, Kosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uno, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morinaga, Yoshitomo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Hiroo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagihara, Katsunori"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-12"}],"displaytype":"detail","filename":"JIC25_262.pdf","filesize":[{"value":"296.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JIC25_262.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/26346/files/JIC25_262.pdf"},"version_id":"85e926ac-395d-411c-a289-0b6749d6725e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Clostridioides difficile","subitem_subject_scheme":"Other"},{"subitem_subject":"Molecular epidemiology","subitem_subject_scheme":"Other"},{"subitem_subject":"Risk factor","subitem_subject_scheme":"Other"},{"subitem_subject":"Toxin gene","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Molecular epidemiology of Clostridioides difficile and risk factors for the detection of toxin gene-positive strains","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular epidemiology of Clostridioides difficile and risk factors for the detection of toxin gene-positive strains"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-12"},"publish_date":"2021-03-12","publish_status":"0","recid":"26346","relation_version_is_last":true,"title":["Molecular epidemiology of Clostridioides difficile and risk factors for the detection of toxin gene-positive strains"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:27:44.962949+00:00"}