{"created":"2023-05-15T16:49:04.261250+00:00","id":26355,"links":{},"metadata":{"_buckets":{"deposit":"0e7a1aff-00d9-4cb2-9435-4723ddcc9b37"},"_deposit":{"created_by":6,"id":"26355","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26355"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026355","sets":["10:11"]},"author_link":["117425","117435","117428","117424","117423","117427","117432","117421","117429","117431","117422","117434","117433","117426","117436","117430","117420"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"137","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"Trials"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Liver cirrhosis is the irreversible fibrosis of the liver and causes refractory ascites and hepatic encephalopathy, which might not respond to treatment. Living donor liver transplantation (LDLT) is an effective treatment for patients with cirrhosis. However, post-LDLT patients are prone to muscle atrophy and sarcopenia. Therefore, physiotherapy of post-LDLT patients is essential for preventing the progression of sarcopenia. Recently, rehabilitation using neuromuscular electrical stimulation (NMES) has been reported to be useful for preventing the progression of sarcopenia. Similarly, nutrition therapy is essential for post-LDLT patients because these patients frequently experience malnutrition. However, the effects of combined NMES and nutrition therapy on post-LDLT patients remain unknown. Methods/design: This open-label, randomized, parallel-group study will compare the effects of combined therapy with NMES and branched-chain amino acids (BCAA) with those of NMES alone in patients with decompensated cirrhosis after LDLT. After LDLT, 50 patients with decompensated cirrhosis will be randomly assigned to receive NMES with BCAA or NMES without BCAA. The duration of the intervention will be 3 months. To analyze the change in skeletal muscle mass, InBody 770 body composition and body water analysis and ultrasonography will be performed before LDLT and 4 weeks and 12 weeks post-LDLT. The primary endpoint is changes in the skeletal muscle mass from baseline to 3 months. Important secondary endpoints are the changes in the skeletal muscle mass from baseline to 1 month and changes in the quadriceps strength from baseline to 1 month. Discussion: The results of this study are expected to provide evidence regarding the effect of NMES combined with BCAA therapy on the skeletal muscle of post-LDLT patients. Trial registration: Japan Registry of Clinical Research jRCTs071190051. Registered on February 26, 2020. ","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Trials, 22(1), art.no.137; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s13063-021-05086-y","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021, The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1745-6215","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Haraguchi, Masafumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichinose, Kunihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyaaki, Hisamitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanada, Masatoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushima, Masanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Ryu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miuma, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Takanobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kugiyama, Tota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Soyama, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hidaka, Masaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuji, Ayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yano, Rintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekino, Motohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahata, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Susumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Kazuhiko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-19"}],"displaytype":"detail","filename":"Trials22_137.pdf","filesize":[{"value":"776.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Trials22_137.pdf ","url":"https://nagasaki-u.repo.nii.ac.jp/record/26355/files/Trials22_137.pdf"},"version_id":"2a0dc993-0d6f-47d8-960f-268dab879611"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Branched-chain amino acids","subitem_subject_scheme":"Other"},{"subitem_subject":"Decompensated cirrhosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Living donor liver transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuromuscular electrical stimulationSarcopenia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparative study of the effect of neuromuscular electrical stimulation and oral administration of branched-chain amino acid on preventing sarcopenia in patients after living-donor liver transplantation: study protocol for an open-label randomized controlled trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparative study of the effect of neuromuscular electrical stimulation and oral administration of branched-chain amino acid on preventing sarcopenia in patients after living-donor liver transplantation: study protocol for an open-label randomized controlled trial"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-19"},"publish_date":"2021-03-19","publish_status":"0","recid":"26355","relation_version_is_last":true,"title":["Comparative study of the effect of neuromuscular electrical stimulation and oral administration of branched-chain amino acid on preventing sarcopenia in patients after living-donor liver transplantation: study protocol for an open-label randomized controlled trial"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:27:11.605361+00:00"}