{"created":"2023-05-15T16:49:04.388235+00:00","id":26358,"links":{},"metadata":{"_buckets":{"deposit":"1844a780-98fc-4dac-add9-3f7291e5b92c"},"_deposit":{"created_by":6,"id":"26358","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26358"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026358","sets":["8:9"]},"author_link":["117471","117469","117478","117470","117476","117475","117472","117477","117468","117467","117474","117473"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"e928858","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Annals of Transplantation"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND Although the risk factors for chronic kidney disease progression after deceased donor liver transplantation have been widely reported, there are few reports describing the factors associated with kidney function changes in patients after living donor liver transplantation (LDLT). This study aims to further investigate these kidney function change factors. MATERIAL AND METHODS This retrospective study was performed using the data of patients who underwent LDLT at the Nagasaki University Hospital, Japan from August 2000 to November 2017. Factors contributing to post-transplantation estimated glomerular filtration rate(eGFR) changes were analyzed. RESULTS A total of 191 cases were reviewed. The average age was 53.8 years, and 108 (56.5%) \npatients were male. Compared to pre-transplantation eGFR levels, eGFR 1 year after LDLT improved in 65 patients (34%) and deteriorated in 126 patients (66%). Multivariate regression analysis revealed that pre-transplant diuretics (P=0.04) and tacrolimus trough value 1 year after transplantation (P=0.04) were significantly associated with elevated eGFR changes. eGFR elevation 1 year after LDLT was more pronounced in patients with a low tacrolimus trough level 1 year after LDLT (P=0.01). Therefore, mycophenolate mofetil was added to tacrolimus in patients with poor renal function before LDLT. CONCLUSIONS Tacrolimus trough level was  associated with eGFR changes 1 year after LDLT. The adjusted dose of tacrolimus and combined use of other immunosuppressants may be important to maintain renal function after LDLT.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Annals of transplantation, 26, e928858; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Scientific Information"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.12659/AOT.928858","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2329-0358","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muta, Kumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, Mineaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hidaka, Masaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Takanobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Soyama, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miuma, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyaaki, Hisamitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Kazuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Susumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mukae, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishino, Tomoya"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-19"}],"displaytype":"detail","filename":"AnnTran26_928858.pdf","filesize":[{"value":"312.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AnnTran26_928858.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/26358/files/AnnTran26_928858.pdf"},"version_id":"e8011981-e964-48d1-ad9d-9b4d891c163f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glomerular Filtration Rate","subitem_subject_scheme":"Other"},{"subitem_subject":"Liver Transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"Living Donors","subitem_subject_scheme":"Other"},{"subitem_subject":"Tacrolimus　","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-19"},"publish_date":"2021-03-19","publish_status":"0","recid":"26358","relation_version_is_last":true,"title":["Association Between Trough Level of Tacrolimus and Change in Estimated Glomerular Filtration Rate 1 Year After Living Donor Liver Transplantation"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:27:05.406655+00:00"}