{"created":"2023-05-15T16:49:21.232909+00:00","id":26772,"links":{},"metadata":{"_buckets":{"deposit":"5836c27c-ddd3-4bf7-b921-783cd4852403"},"_deposit":{"created_by":6,"id":"26772","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26772"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026772","sets":["10:11"]},"author_link":["118600","118596","118592","118593","118599","118598","118594","118597","118595"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"art. no. e0244120","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Macrophage accumulation in response to decreasing myonuclei may be the major mechanism underlying immobilization-induced muscle fibrosis in muscle contracture, an intervention strategy suppressing these lesions is necessary. Therefore, this research investigated the effect of belt electrode-skeletal muscle electrical stimulation (B-SES), a new electrical stimulation device, to the macrophage accumulation via myonuclei decrease in immobilization-induced muscle fibrosis.\nMaterials and methods: 18 Wistar male rats were divided into the control group, immobilization group (with plaster cast fixation to immobilize the soleus muscles in a shortened position for 2 weeks), and B-SES group (with muscle contractile exercise through B-SES during the immobilization period). B-SES stimulation was performed at a frequency of 50 Hz and an intensity of 4.7 mA, muscle contractile exercise by B-SES was applied to the lower limb muscles for 20 minutes/session (twice a day) for 2 weeks (6 times/week). The bilateral soleus muscles were used for histological, immunohistochemical, biochemical, and molecular biological analyses.\nResults: The number of myonuclei was significantly higher in the B-SES group than in the immobilization group, and there was no significant difference between the B-SES and control groups. The cross-sectional area of type I and II myofibers in the immobilization and B-SES groups was significantly lower than that in the control group, and the cross-sectional area of type I myofibers in the B-SES group was higher than that in the immobilization group. However, Atrogin-1 and MuRF-1 mRNA expression in the immobilization and B-SES groups was significantly higher than those in the control group. Additionally, the number of macrophages, IL-1β, TGF-β1, and α-SMA mRNA expression, and hydroxyproline expression was significantly lower in the control and B-SES groups than those in the immobilization group.\nConclusion: This research surmised that muscle contractile exercise through B-SES prevented immobilization-induced muscle fibrosis, and this alteration suppressed the development of muscle contracture.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS ONE, 16(5), art. no. e0244120; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0244120","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 Honda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Honda, Yuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Natsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kajiwara, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Yasutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kataoka, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akimoto, Ryuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nawata, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okita, Minoru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-12"}],"displaytype":"detail","filename":"PLoS16_e0244120.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLoS16_e0244120.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/26772/files/PLoS16_e0244120.pdf"},"version_id":"178d8822-9d42-40bd-b255-9ffb5ebaaac9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of belt electrode-skeletal muscle electrical stimulation on immobilizationinduced muscle fibrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of belt electrode-skeletal muscle electrical stimulation on immobilizationinduced muscle fibrosis"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-12"},"publish_date":"2021-10-12","publish_status":"0","recid":"26772","relation_version_is_last":true,"title":["Effect of belt electrode-skeletal muscle electrical stimulation on immobilizationinduced muscle fibrosis"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:12:07.765233+00:00"}