@article{oai:nagasaki-u.repo.nii.ac.jp:00026804,
 author = {Kaneko, Shohei and Ichinomiya, Taiga and Sato, Shuntaro and Sekino, Motohiro and Murata, Hiroaki and Hara, Tetsuya},
 issue = {2},
 journal = {Annals of Cardiac Anaesthesia},
 month = {Apr},
 note = {Context: Postoperative hyperthermia, which may lead to cognitive decline, is a common complication of cardiovascular surgery with cardiopulmonary bypass (CPB).
Aims: The aim of this study was to examine the effectiveness of perioperative intravenous acetaminophen on body temperature in adult patients after cardiovascular surgery with CPB.
Settings and Design: This was a single-center retrospective study focusing on adult patients who underwent elective cardiovascular surgery with CPB at a university hospital in Japan.
Subjects and Methods: Patients were divided into two groups based on whether they received acetaminophen perioperatively. In the acetaminophen group, 15 mg/kg intravenous acetaminophen solution was infused at 30 min after discontinuation of CPB and every 6 h after intensive care unit (ICU) admission.
Statistical Analysis Used: The primary outcome was the maximum axillary temperature within 12 h after ICU admission. The effects of acetaminophen on postoperative body temperature were estimated by the standardization and inverse probability weighting using propensity scores.
Results: A total of 201 patients were included in the final analysis (acetaminophen group, n = 101; non-acetaminophen group, n = 100). The maximum axillary temperature within 12 h after ICU admission was 37.20 ± 0.54°C in the acetaminophen group and 37.78 ± 0.59°C in the non-acetaminophen group. Acetaminophen lowered the standardized mean of primary endpoint (?0.54°C, 95% confidence interval, ?0.69 to ?0.38) compared to non-acetaminophen.
Conclusions: Perioperative intravenous acetaminophen inhibited body temperature elevation after cardiovascular surgery with CPB, compared with the non-acetaminophen group., Annals of Cardiac Anaesthesia, 24 (2), pp. 155-162; 2021},
 pages = {155--162},
 title = {Effect of perioperative acetaminophen on body temperature after cardiovascular surgery with cardiopulmonary bypass: A single-center retrospective study},
 volume = {24},
 year = {2021}
}