{"created":"2023-05-15T16:49:23.155638+00:00","id":26819,"links":{},"metadata":{"_buckets":{"deposit":"abc557fa-462e-4548-b204-fce2e9f1aa62"},"_deposit":{"created_by":6,"id":"26819","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26819"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026819","sets":["10:11"]},"author_link":["118802","118803","118798","118800","118801","118804","118799"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-05-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"art. no. 5364","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hydrocarbon stapling is a useful tool for stabilizing the secondary structure of peptides. Among several methods, hydrocarbon stapling at i,i + 1 positions was not extensively studied,  and their secondary structures are not clarified. In this study, we investigate i,i + 1 hydrocarbon stapling between cis-4-allyloxy-L-proline and various olefin-tethered amino acids. Depending on the ring size of the stapled side chains and structure of the olefin-tethered amino acids, E- or Z-selectivities were observed during the ring-closing metathesis reaction (E/Z was up to 8.5:1 for 17–14-membered rings and up to 1:20 for 13-membered rings). We performed X-ray crystallographic analysis of hydrocarbon stapled peptide at i,i + 1 positions. The X-ray crystallographic structure suggested that the i,i + 1 staple stabilizes the peptide secondary structure to the right-handed α-helix. These findings are especially important for short oligopeptides because the employed stapling method uses two minimal amino acid residues adjacent to each other.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"International Journal of Molecular Sciences, 22(10), art. no. 5364; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms22105364","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Makura, Yui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueda, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Takuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iyoshi, Akihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higuchi, Mei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Doi, Mitsunobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Masakazu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-27"}],"displaytype":"detail","filename":"IJMS22_5364.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IJMS22_5364.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/26819/files/IJMS22_5364.pdf"},"version_id":"7315c072-ed76-4296-88a3-eaa20ca10960"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"α-helix","subitem_subject_scheme":"Other"},{"subitem_subject":"hydrocarbon stapling","subitem_subject_scheme":"Other"},{"subitem_subject":"ring-closingmetathesis","subitem_subject_scheme":"Other"},{"subitem_subject":"i,i + 1 staple","subitem_subject_scheme":"Other"},{"subitem_subject":"X-ray structure","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"X-ray crystallographic structure of α-helical peptide stabilized by hydrocarbon stapling at i,i + 1 positions","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"X-ray crystallographic structure of α-helical peptide stabilized by hydrocarbon stapling at i,i + 1 positions"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-27"},"publish_date":"2021-10-27","publish_status":"0","recid":"26819","relation_version_is_last":true,"title":["X-ray crystallographic structure of α-helical peptide stabilized by hydrocarbon stapling at i,i + 1 positions"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:11:12.379445+00:00"}