@article{oai:nagasaki-u.repo.nii.ac.jp:00026842,
 author = {Tashiro, Masato and Takazono, Takahiro and Ota, Yuki and Wakamura, Tomotaro and Takahashi, Akinori and Sato, Kumiko and Miyazaki, Taiga and Obata, Yoko and Nishino, Tomoya and Izumikawa, Koichi},
 issue = {10},
 journal = {Journal of Infection and Chemotherapy},
 month = {Jun},
 note = {Introduction: Liposomal amphotericin B (L-AMB), a broad spectrum anti-fungicidal drug, is often administered to treat invasive fungal infections (IFIs). However, the most suitable time to initiate treatment in septic shock patients with IFI is unknown.
Methods: Patients with septic shock treated with L-AMB were identified from the Japanese Diagnosis Procedure Combination national database and were stratified according to L-AMB treatment initiation either at septic shock onset (early L-AMB group) or after the onset (delayed L-AMB group) to determine their survival rates following septic shock onset and the shock cessation period.
Results: We identified 141 patients administered L-AMB on the day of or after septic shock onset: 60 patients received early treatment, whereas 81 patients received delayed treatment. Survival rates after septic shock onset were higher in the early L-AMB group than in the delayed L-AMB group (4 weeks: 68.4% vs 57.9%, P = 0.197; 6 weeks: 62.2% vs 44.5%, P = 0.061; 12 weeks: 43.4% vs 35.0%, P = 0.168, respectively). The septic shock cessation period was shorter in the early L-AMB group than in the delayed L-AMB group (7.0 ± 7.0 days vs 16.5 ± 15.4 days, P < 0.001), with a significant difference confirmed after adjusting for confounding factors with propensity score matching (7.1 ± 7.2 days vs 16.7 ± 14.0 days, P = 0.001).
Conclusion: Early L-AMB administration at septic shock onset may be associated with early shock cessation., Journal of Infection and Chemotherapy, 27 (10), pp. 1471-1476; 2021},
 pages = {1471--1476},
 title = {Efficacy of early administration of liposomal amphotericin B in patients with septic shock: A nationwide observational study},
 volume = {27},
 year = {2021}
}