{"created":"2023-05-15T16:49:24.152804+00:00","id":26842,"links":{},"metadata":{"_buckets":{"deposit":"0b392dae-a53d-4e78-8c1c-4d4d2eebf160"},"_deposit":{"created_by":6,"id":"26842","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26842"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026842","sets":["29:30"]},"author_link":["119027","119026","119020","119024","119028","119019","119022","119021","119025","119023"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1476","bibliographicPageStart":"1471","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Journal of Infection and Chemotherapy"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: Liposomal amphotericin B (L-AMB), a broad spectrum anti-fungicidal drug, is often administered to treat invasive fungal infections (IFIs). However, the most suitable time to initiate treatment in septic shock patients with IFI is unknown.\nMethods: Patients with septic shock treated with L-AMB were identified from the Japanese Diagnosis Procedure Combination national database and were stratified according to L-AMB treatment initiation either at septic shock onset (early L-AMB group) or after the onset (delayed L-AMB group) to determine their survival rates following septic shock onset and the shock cessation period.\nResults: We identified 141 patients administered L-AMB on the day of or after septic shock onset: 60 patients received early treatment, whereas 81 patients received delayed treatment. Survival rates after septic shock onset were higher in the early L-AMB group than in the delayed L-AMB group (4 weeks: 68.4% vs 57.9%, P = 0.197; 6 weeks: 62.2% vs 44.5%, P = 0.061; 12 weeks: 43.4% vs 35.0%, P = 0.168, respectively). The septic shock cessation period was shorter in the early L-AMB group than in the delayed L-AMB group (7.0 ± 7.0 days vs 16.5 ± 15.4 days, P < 0.001), with a significant difference confirmed after adjusting for confounding factors with propensity score matching (7.1 ± 7.2 days vs 16.7 ± 14.0 days, P = 0.001).\nConclusion: Early L-AMB administration at septic shock onset may be associated with early shock cessation.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Infection and Chemotherapy, 27 (10), pp. 1471-1476; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jiac.2021.06.013","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341321X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tashiro, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takazono, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakamura, Tomotaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Akinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Kumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Taiga"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Obata, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishino, Tomoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumikawa, Koichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-09"}],"displaytype":"detail","filename":"JIC27_1471.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JIC27_1471.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/26842/files/JIC27_1471.pdf"},"version_id":"43045214-388d-4e28-a5db-7dca02abec96"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Liposomal amphotericin B","subitem_subject_scheme":"Other"},{"subitem_subject":"Mortality","subitem_subject_scheme":"Other"},{"subitem_subject":"Septic shock","subitem_subject_scheme":"Other"},{"subitem_subject":"Early administration","subitem_subject_scheme":"Other"},{"subitem_subject":"Observational study","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Efficacy of early administration of liposomal amphotericin B in patients with septic shock: A nationwide observational study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Efficacy of early administration of liposomal amphotericin B in patients with septic shock: A nationwide observational study"}]},"item_type_id":"2","owner":"6","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-09"},"publish_date":"2021-11-09","publish_status":"0","recid":"26842","relation_version_is_last":true,"title":["Efficacy of early administration of liposomal amphotericin B in patients with septic shock: A nationwide observational study"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:09:47.465046+00:00"}