{"created":"2023-05-15T16:49:24.662644+00:00","id":26856,"links":{},"metadata":{"_buckets":{"deposit":"1a4b9e91-7c52-4f75-97c4-ea3ae03208a9"},"_deposit":{"created_by":6,"id":"26856","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26856"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026856","sets":["8:9"]},"author_link":["119142","119139","119141","119144","119145","119146","119143","119149","119147","119148","119140"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-07-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"art. no. 14146","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Septic shock is characterized by dysregulated vascular permeability. We hypothesized that the vascular permeability of endothelial cells (ECs) would be regulated by serotonin via serotonin-Rho-associated kinase (ROCK) signaling. We aimed to determine the impact of 5-hydroxyindoleacetic acid (5-HIAA) on septic shock as a novel biomarker. Plasma 5-HIAA levels and disease severity indices were obtained from 47 patients with sepsis. The association between 5-HIAA levels and severity indices was analyzed. Permeability upon serotonin stimulation was determined using human pulmonary microvascular ECs. 5-HIAA were significantly higher in septic shock patients than in patients without shock or healthy controls (p = 0.004). These elevated levels were correlated with severity indexes (SOFA score [p < 0.001], APACHE II [p < 0.001], and PaO2:FiO2 [p = 0.02]), and longitudinally associated with worse clinical outcomes (mechanical ventilation duration [p = 0.009] and ICU duration [p = 0.01]). In the experiment, serotonin increased the permeability of ECs, which was inhibited by the ROCK inhibitor (p < 0.001). Serotonin increases vascular permeability of ECs via ROCK signaling. This suggests a novel mechanism by which serotonin disrupts endothelial barriers via ROCK signaling and causes the pathogenesis of septic shock with a vascular leak. Serotonin serves as a novel biomarker of vascular permeability.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 11, art. no. 14146; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-021-93649-z","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Masahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekino, Motohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashijima, Ushio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takaki, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Yoshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kakiuchi, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tashiro, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morimoto, Konosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tasaki, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumikawa, Koichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-15"}],"displaytype":"detail","filename":"SciRep11_14146.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep11_14146.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/26856/files/SciRep11_14146.pdf"},"version_id":"aac85720-eafa-4f61-ab44-a65dea71b7a4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Impact of plasma 5-hydroxyindoleacetic acid, a serotonin metabolite, on clinical outcome in septic shock, and its effect on vascular permeability","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impact of plasma 5-hydroxyindoleacetic acid, a serotonin metabolite, on clinical outcome in septic shock, and its effect on vascular permeability"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-15"},"publish_date":"2021-11-15","publish_status":"0","recid":"26856","relation_version_is_last":true,"title":["Impact of plasma 5-hydroxyindoleacetic acid, a serotonin metabolite, on clinical outcome in septic shock, and its effect on vascular permeability"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:09:04.824999+00:00"}