{"created":"2023-05-15T16:49:25.440091+00:00","id":26874,"links":{},"metadata":{"_buckets":{"deposit":"b3027af9-347d-45fc-8a47-84cb270f5c33"},"_deposit":{"created_by":6,"id":"26874","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26874"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026874","sets":["25:26"]},"author_link":["119323","119328","119321","119319","119325","119326","119329","119320","119318","119324","119332","119322","119330","119331","119327"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"16260","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), are chronic intestinal diseases of unknown etiology that present with variable disease extents and outcomes. The use of biomarkers for the diagnosis and management of IBDs is considered beneficial. Palmitoleic acid (PO) is an adipose tissue-derived mono-unsaturated free fatty acid that potentially serves as a lipokine in metabolic and inflammatory diseases. The aim of this study was to investigate the significance of PO levels in the serum of patients with UC and CD. The study included patients with UC (n = 22), patients with CD (n = 35), and controls (n = 22). The levels of serum PO were analyzed using gas chromatography. The association of serum PO levels with the clinical features and disease outcomes in IBD was examined. Serum PO levels were significantly higher in patients with CD than in controls, whereas no difference in these levels was observed between patients with UC and controls. Serum PO levels were significantly associated with the CD activity index. Additionally, high serum PO levels were associated with an increased risk of surgical intervention requirement during follow-up. In a pilot study with a few patients, high PO levels were observed in the mesenteric tissue in the active disease site of patients with CD (n = 7) compared with those with colon cancer (n = 6). Elevated serum PO levels might serve as a marker for local inflammation and prognosis in patients with CD.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 11, art. no. 16260; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-021-95923-6","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or  format,  as  long  as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this  article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akazawa, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morisaki, Tomohito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Norimatsu, Kiyuu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiota, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashiguchi, Keiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tabuchi, Maiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitayama, Moto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsushima, Kayoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Naoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Hisayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Fumihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeshita, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Kazuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeshima, Fuminao"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-19"}],"displaytype":"detail","filename":"SciRep11_16260.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep11_16260.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/26874/files/SciRep11_16260.pdf"},"version_id":"6b332e02-a869-4ee0-8a26-0eac92d195a0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Significance of serum palmitoleic acid levels in inflammatory bowel disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Significance of serum palmitoleic acid levels in inflammatory bowel disease"}]},"item_type_id":"2","owner":"6","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-19"},"publish_date":"2021-11-19","publish_status":"0","recid":"26874","relation_version_is_last":true,"title":["Significance of serum palmitoleic acid levels in inflammatory bowel disease"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:08:15.827205+00:00"}