{"created":"2023-05-15T16:49:26.525300+00:00","id":26900,"links":{},"metadata":{"_buckets":{"deposit":"50504f37-6798-4643-81db-90e99cd4834d"},"_deposit":{"created_by":6,"id":"26900","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26900"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026900","sets":["35:36"]},"author_link":["119575","119578","119574","119585","119577","119581","119582","119576","119579","119580","119584","119583","119573"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageStart":"e0009670","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"PLOS Neglected Tropical Diseases"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Fever with jaundice is a common symptom of some infectious diseases. In public health surveillance within the Democratic Republic of the Congo (DRC), yellow fever is the only recognized cause of fever with jaundice. However, only 5% of the surveillance cases are positive for yellow fever and thus indicate the involvement of other pathogens. Leptospira spp. are the causative agents of leptospirosis, a widespread bacterial zoonosis, a known cause of fever with jaundice. This study aimed to determine the seropositivity of anti-Leptospira antibodies among suspected yellow fever cases and map the geographical distribution of possible leptospirosis in the DRC.\nMethods: We conducted a retrospective study using 1,300 samples from yellow fever surveillance in the DRC from January 2017 to December 2018. Serum samples were screened for the presence of IgM against Leptospira spp. by a whole cell-based IgM ELISA (Patoc-IgM ELISA) at the Institut National de Recherche Biomedicale in Kinshasa (INRB) according to World Health Organization (WHO) guidance. Exploratory univariable and multivariable logistic regression analyses were undertaken to assess associations between socio-demographic factors and the presence of Leptospira IgM.\nResults: Of the 1,300 serum samples screened, 88 (7%) showed evidence of IgM against Leptospira spp. Most positive cases (34%) were young adult males in the 20–29-year group. There were statistically significant associations between having Leptospira IgM antibodies, age, sex, and living area. Observed positive cases were mostly located in urban settings, and the majority lived in the province of Kinshasa. There was a statistically significant association between seasonality and IgM Leptospira spp. positivity amongst those living in Kinshasa, where most of the positive cases occurred during the rainy season.\nConclusions: This study showed that leptospirosis is likely an overlooked cause of unexplained cases of fever with jaundice in the DRC and highlights the need to consider leptospirosis in the differential diagnosis of fever with jaundice, particularly in young adult males. Further studies are needed to identify animal reservoirs, associated risk factors, and the burden of human leptospirosis in the DRC.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS Neglected Tropical Diseases, 15(8), art. no. e0009670; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pntd.0009670","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 Mukadi Kakoni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1935-2735","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mukadi Kakoni, Patrick"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Munyeku Bazitama, Yannick"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nepomuceno, Jean Raphael"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pukuta-Simbu, Elisabeth"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawhata Mawika, Francois"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kashitu Mujinga, Gracia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Palla, Luigi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ahuka-Mundeke, Steve"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muyembe Tamfum, Jean-Jacques"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koizumi, Nobuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Yoshinao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ariyoshi, Koya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Smith, Chris"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-26"}],"displaytype":"detail","filename":"PNTD15_e0009670.pdf","filesize":[{"value":"707.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PNTD15_e0009670.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/26900/files/PNTD15_e0009670.pdf"},"version_id":"ff532fc0-afe8-4448-a8a9-e9e331f1852b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Leptospirosis as a cause of fever associated with jaundice in the Democratic Republic of the Congo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Leptospirosis as a cause of fever associated with jaundice in the Democratic Republic of the Congo"}]},"item_type_id":"2","owner":"6","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-26"},"publish_date":"2021-11-26","publish_status":"0","recid":"26900","relation_version_is_last":true,"title":["Leptospirosis as a cause of fever associated with jaundice in the Democratic Republic of the Congo"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:07:14.857508+00:00"}