{"created":"2023-05-15T16:49:27.506277+00:00","id":26922,"links":{},"metadata":{"_buckets":{"deposit":"946e403b-b479-48e8-8a6b-22b9bf39bd05"},"_deposit":{"created_by":6,"id":"26922","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"26922"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00026922","sets":["25:26"]},"author_link":["119726","119732","119725","119727","119729","119730","119724","119731","119728"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"art. no. 19096","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Childhood radiation exposure is a known thyroid cancer risk factor. This study evaluated the effects of age on radiation-induced thyroid carcinogenesis in rats irradiated with 8 Gy X-rays. We analyzed cell proliferation, cell death, DNA damage response, and autophagy-related markers in 4-week-old (4W) and 7-month-old (7M) rats and the incidence of thyroid tumors in 4W, 4-month-old (4M), and 7M rats 18 months after irradiation. Cell death and DNA damage response were increased in 4W rats compared to those in controls at 1 month post-irradiation. More Ki-67-positive cells were observed in 4W rats at 12 months post-irradiation. Thyroid tumors were confirmed in 61.9% (13/21), 63.6% (7/11), and 33.3% (2/6) of irradiated 4W, 4M, and 7M rats, respectively, compared to 0%, 14.3% (1/7), and 16.7% (1/6) in the respective nonirradiated controls. There were 29, 9, and 2 tumors in irradiated 4W, 4M, and 7M rats, respectively. The expression of several autophagy components was downregulated in the area surrounding radiation-induced thyroid carcinomas in 4W and 7M rats. LC3 and p62 expression levels decreased in radiation-induced follicular carcinoma in 4W rats. Radiosensitive cells causing thyroid tumors may be more prevalent in young rats, and abrogation of autophagy may be associated with radiation-induced thyroid carcinogenesis.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 11, art. no. 19096; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-021-98481-z","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuu-Matsuyama, Mutsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shichijo, Kazuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Katsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, Nariaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Hisayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Shiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurashige, Tomomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagayama, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Masahiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-12-08"}],"displaytype":"detail","filename":"SciRep11_19096.pdf","filesize":[{"value":"6.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep11_19096.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/26922/files/SciRep11_19096.pdf"},"version_id":"0085cc3e-c391-42e2-91a4-7b1adc2a85ce"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid"}]},"item_type_id":"2","owner":"6","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-12-08"},"publish_date":"2021-12-08","publish_status":"0","recid":"26922","relation_version_is_last":true,"title":["Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:06:14.488763+00:00"}