@article{oai:nagasaki-u.repo.nii.ac.jp:00026927,
 author = {Yamashita, Hiromi and Zeredo, Jorge Luis Lopes and Toda, Kazuo},
 issue = {4},
 journal = {Journal of Acupuncture and Meridian Studies},
 month = {Aug},
 note = {Background: Electroacupuncture is one of the most popular physical treatments for clinical pain, but the potential influence of a patient’s age on the effectiveness of electroacupuncture treatment has not been clearly established. Objectives: The present study aimed to detect a potential difference in electroacupuncture- induced analgesia between juvenile and adult rats.
Methods: In this study, we investigated the effects of electroacupuncture treatment on the nociceptive jaw-opening reflex evoked by tooth-pulp stimulation in juvenile and adult rats.
Results: Our results showed there were age differences in electroacupuncture-induced analgesic effects in rats, especially with naloxone antagonization. The ratio of naloxonereversibility against electroacupuncture analgesia was greater in adult rats than in juvenile rats.
Conclusion: These results suggest that electroacupuncture analgesia is produced mainly by the non-opioid system in juvenile rats and by the opioid system in adult rats., Journal of Acupuncture and Meridian Studies, 14(4), pp. 167-172; 2021},
 pages = {167--172},
 title = {Age Differences in Naloxone Reversibility of Electroacupuncture on the Jaw Opening Reflex in Rats},
 volume = {14},
 year = {2021}
}