@phdthesis{oai:nagasaki-u.repo.nii.ac.jp:00026966,
 author = {松本, 舞},
 month = {Mar},
 note = {Background: Oral allergy syndrome (OAS) is an IgE-mediated food allergy. Ingestion of causative antigens leads to the development of local symptoms such as numbness of the oral mucosa in most cases and anaphylaxis in a few cases. The prevalence of OAS including in healthy people has not been investigated. Thus, we conducted a questionnaire survey of Japanese university students.
Methods: We conducted a cross-sectional study of 2688 first-year students using a questionnaire survey in marksheet format and examined the epidemiological characteristics of OAS.
Results: Only 2.7% of students were aware of the term “oral allergy syndrome”. A total of 143 (5.3%) students had OAS. There were significant associations between OAS and other allergic diseases including allergic rhinitis (AR) (OR: 3.8, 95% CI: 2.7–5.5), atopic dermatitis (AD) (OR: 4.6, 95%CI: 3.3–6.6), and bronchial asthma (BA) (OR: 3.0, 95%CI: 2.0–4.5). The onset age of OAS showed bimodal peaks at 0 and 10 years, and the latter peak coincided with the peak onset age of AR.
Conclusions: Awareness of OAS was low in our study, which will make it difficult to treat properly and prevent its development. This survey confirmed the association between OAS and other allergic diseases, especially AR, which suggests that OAS is involved in the allergic march. A novel finding was that sensitization to antigens for OAS occurred around the same time as sensitization to antigens for AR. These results will help medical professionals diagnose OAS and develop lifestyle guidelines to prevent OAS-related symptoms such as anaphylaxis., 長崎大学学位論文 学位記番号:博(医歯薬)甲第1350号 学位授与年月日:令和3年6月2日, Author: Mai Matsumoto, Motoi Takenaka, Kiyoshi Aoyagi, Yoshihito Tomita, Kazuhiko Arima, Keiko Yamauchi-Takihara, Hiroyuki Murota, Citation: Allergology International, 70(4), pp. 458-462; 2021, Nagasaki University (長崎大学), 博士(医学) (2021-06-02)},
 school = {Nagasaki University (長崎大学)},
 title = {Factors associated with the development of oral allergy syndrome: A retrospective questionnaire survey of Japanese university students},
 year = {2021}
}