{"created":"2023-05-15T16:49:30.969272+00:00","id":27003,"links":{},"metadata":{"_buckets":{"deposit":"422acdf0-5d70-4b4d-94c6-543d866eb83e"},"_deposit":{"created_by":6,"id":"27003","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27003"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027003","sets":["35:36"]},"author_link":["120162","120160","120161","120163","120159","120164"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"art. no. 21259","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently a serious public health concern worldwide. Notably, co-infection with other pathogens may worsen the severity of COVID-19 symptoms and increase fatality. Here, we show that co-infection with influenza A virus (IAV) causes more severe body weight loss and more severe and prolonged pneumonia in SARS-CoV-2-infected hamsters. Each virus can efficiently spread in the lungs without interference by the other. However, in immunohistochemical analyses, SARS-CoV-2 and IAV were not detected at the same sites in the respiratory organs of co-infected hamsters, suggesting that either the two viruses may have different cell tropisms in vivo or each virus may inhibit the infection and/or growth of the other within a cell or adjacent areas in the organs. Furthermore, a significant increase in IL-6 was detected in the sera of hamsters co-infected with SARS-CoV-2 and IAV at 7 and 10 days post-infection, suggesting that IL-6 may be involved in the increased severity of pneumonia. Our results strongly suggest that IAV co-infection with SARS-CoV-2 can have serious health risks and increased caution should be applied in such cases.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 11(1), art. no. 21259; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-021-00809-2","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licen ses/by/4.0/."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kinoshita, Takaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Kenichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai, Yasuteru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishi, Kodai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshikawa, Rokusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasuda, Jiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-20"}],"displaytype":"detail","filename":"SciRep11_21259.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep11_21259.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27003/files/SciRep11_21259.pdf"},"version_id":"00a70d77-02f8-4033-b3ef-23b768248dd0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamsters","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamsters"}]},"item_type_id":"2","owner":"6","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-20"},"publish_date":"2022-01-20","publish_status":"0","recid":"27003","relation_version_is_last":true,"title":["Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamsters"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:03:43.581233+00:00"}