{"created":"2023-05-15T16:49:31.733407+00:00","id":27021,"links":{},"metadata":{"_buckets":{"deposit":"dc46659e-d749-4b4f-aa70-1d74b3bfaca6"},"_deposit":{"created_by":6,"id":"27021","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27021"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027021","sets":["8:9"]},"author_link":["120290","120291","120284","120289","120294","120288","120286","120293","120292","120285","120287"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"art. no. 293","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"BMC Anesthesiology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The required fluid volume differs among patients with septic shock. Enterocyte injury caused by shock may increase the need for fluid by triggering a systematic inflammatory response or an ischemia-reperfusion injury in the presence of intestinal ischemia/necrosis. This study aimed to evaluate the association between enterocyte injury and positive fluid balance in patients with septic shock.\nMethods: This study was a post hoc exploratory analysis of a prospective observational study that assessed the association between serum intestinal fatty acid-binding protein, a biomarker of enterocyte injury, and mortality in patients with septic shock. Intestinal fatty acid-binding protein levels were recorded on intensive care unit admission, and fluid balance was monitored from intensive care unit admission to Day 7. The association between intestinal fatty acid-binding protein levels at admission and the infusion balance during the early period after intensive care unit admission was evaluated. Multiple linear regression analysis, with adjustments for severity score and renal function, was performed.\nResults: Overall, data of 57 patients were analyzed. Logarithmically transformed intestinal fatty acid-binding protein levels were significantly associated with cumulative fluid balance per body weight at 24 and 72 h post-intensive care unit admission both before (Pearson’s r = 0.490 [95% confidence interval: 0.263–0.666]; P < 0.001 and r = 0.479 [95% confidence interval: 0.240–0.664]; P < 0.001, respectively) and after (estimate, 14.4 [95% confidence interval: 4.1–24.7]; P = 0.007 and estimate, 26.9 [95% confidence interval: 11.0–42.7]; P = 0.001, respectively) adjusting for severity score and renal function.\nConclusions: Enterocyte injury was significantly associated with cumulative fluid balance at 24 and 72 h post-intensive care unit admission. Enterocyte injury in patients with septic shock may be related to excessive fluid accumulation during the early period after intensive care unit admission","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"BMC Anesthesiology, 21, art. no. 293; 2021","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12871-021-01515-2","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1471-2253","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yokoyama, Haruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekino, Motohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Funaoka, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shuntaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Araki, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Egashira, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yano, Rintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Sojiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichinomiya, Taiga"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashijima, Ushio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Tetsuya"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-24"}],"displaytype":"detail","filename":"BMCA21_293.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BMCA21_293.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27021/files/BMCA21_293.pdf"},"version_id":"98a68b4a-32cb-4801-a5e7-fd05e971f42f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Enterocyte damage","subitem_subject_scheme":"Other"},{"subitem_subject":"Fluid administration","subitem_subject_scheme":"Other"},{"subitem_subject":"Fluid volume","subitem_subject_scheme":"Other"},{"subitem_subject":"Intensive care unit","subitem_subject_scheme":"Other"},{"subitem_subject":"Intestinal fatty acid-binding protein","subitem_subject_scheme":"Other"},{"subitem_subject":"Intestinal mucosal cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Sepsis","subitem_subject_scheme":"Other"},{"subitem_subject":"Septic shock","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-24"},"publish_date":"2022-01-24","publish_status":"0","recid":"27021","relation_version_is_last":true,"title":["Association between enterocyte injury and fluid balance in patients with septic shock: a post hoc exploratory analysis of a prospective observational study"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T20:03:00.427047+00:00"}