@article{oai:nagasaki-u.repo.nii.ac.jp:00027119,
 author = {Yamashita, Koki and Fukuda, Yuichi and Yoshikawa, Rokusuke and Tanaka, Yasuhiro and Yoshida, Masataka and Umemura, Asuka and Kobayashi, Tsutomu and Soda, Hiroshi and Yasuda, Jiro and Izumikawa, Koichi and Yanagihara, Katsunori and Mukae, Hiroshi and Kohno, Shigeru},
 issue = {2},
 journal = {Acta medica Nagasakiensia},
 month = {Jan},
 note = {The relationship between the severity of COVID-19, hyperinflammation, and intravascular oagulopathy is of critical importance. We report on a case of severe COVID-19 pneumonia treated with favipiravir during the earliest phase of the pandemic. The present case showed improvement in SARS-CoV-2 viral load and the presence of SARS-CoV-2 IgG with decreased radiological evidence of pulmonary infiltration. Moreover, the levels of serum IL-6 and TNF-α did not increase markedly. However, the hypoxia failed to recover, leading to the patient’s death due to possible pulmonary thrombosis, because D-dimer was markedly elevated, and an electrocardiogram showed typical changes. At present, the fact that some COVID-19 patients with mild to moderate symptoms suddenly die at home has become a major issue in Japan. These findings suggest that additional treatment with anti-coagulants should be considered in some COVID-19 patients at risk of ypercoagulation to prevent sudden death from pulmonary thrombosis., Acta medica Nagasakiensia, 65(2), pp.67-71; 2022},
 pages = {67--71},
 title = {A fatal case of COVID-19 pneumonia due to possible pulmonary thrombosis},
 volume = {65},
 year = {2022}
}