{"created":"2023-05-15T16:49:36.272010+00:00","id":27120,"links":{},"metadata":{"_buckets":{"deposit":"279b647c-e920-4da6-89d7-9a006417485b"},"_deposit":{"created_by":6,"id":"27120","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27120"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027120","sets":["29:30:1713167819629:2019"]},"author_link":["120860"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"75","bibliographicPageStart":"73","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Acute exposure to hypoxia generally increase the ventilation. However, some of COVID-19 patients who suffer from pneumonia are characterized by hypoxic ventilatory depression with loss of dyspnea which is called as happy hypoxia. This report describes the background and the clinical issues of happy hypoxia.\nMethods: The mechanisms to increase ventilation and dyspnea under hypoxia are explained. Further, clinical issues and characteristics in COVID-19 are reviewed.\nResults: Genetic factors are definitely concerned with chemosensitivity to hypoxia. Further disease factors including COVID-19 infection could influence the attenuation of the chemosensitivity. This can be attributed to either ventilatory depression due to the modulation of metabolic substrate, adenosine in the brain, or autonomic neuropathy including the dysfunction of the carotid body.\nConclusions: COVID-19 patients must be carefully treated and/or monitored to avoid hypoxic ventilator depression. The clinical application of aminophylline will be an issue to be considered.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia, 65(2), pp.73−75; 2022","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagasaki University School of Medicine"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"07"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"長崎大学医学部"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kimura, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-25"}],"displaytype":"detail","filename":"ActMed65_73.pdf","filesize":[{"value":"463.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ActMed65_73.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27120/files/ActMed65_73.pdf"},"version_id":"488cb63c-06da-493e-bb1c-2751109d5990"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"COVID-19","subitem_subject_scheme":"Other"},{"subitem_subject":"hypoxia","subitem_subject_scheme":"Other"},{"subitem_subject":"dyspnea","subitem_subject_scheme":"Other"},{"subitem_subject":"ventilation","subitem_subject_scheme":"Other"},{"subitem_subject":"chemosensitivity","subitem_subject_scheme":"Other"},{"subitem_subject":"carotid body","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Happy hypoxia in COVID-19 patients associated with hypoxic ventilatory depression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Happy hypoxia in COVID-19 patients associated with hypoxic ventilatory depression"}]},"item_type_id":"3","owner":"6","path":["2019"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-25"},"publish_date":"2022-02-25","publish_status":"0","recid":"27120","relation_version_is_last":true,"title":["Happy hypoxia in COVID-19 patients associated with hypoxic ventilatory depression"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2024-04-18T01:20:41.588773+00:00"}