@article{oai:nagasaki-u.repo.nii.ac.jp:00027141,
 author = {Nakano, Masahito and Yatsuhashi, Hiroshi and Bekki, Shigemune and Takami, Yuko and Tanaka, Yasuhito and Yoshimaru, Yoko and Honda, Koichi and Komorizono, Yasuji and Harada, Masaru and Shibata, Michihiko and Sakisaka, Shotaro and Shakado, Satoshi and Nagata, Kenji and Yoshizumi, Tomoharu and Itoh, Shinji and Sohda, Tetsuro and Oeda, Satoshi and Nakao, Kazuhiko and Sasaki, Ryu and Yamashita, Tsutomu and Ido, Akio and Mawatari, Seiichi and Nakamuta, Makoto and Aratake, Yoshifusa and Matsumoto, Shuichi and Maeshiro, Tatsuji and Goto, Takashi and Torimura, Takuji},
 journal = {Scientific Reports},
 month = {Jan},
 note = {We examined the epidemiological trends, including the distribution of sex, age, and disease etiology, in HCC incident cases, over 24 years. Data of 20,547 HCC patients (1996–2019) were analyzed in this prospective study. We divided the study period into four 6-yearly quarters. HCC etiology was categorized as hepatitis B virus (HBV) infection, HBV + hepatitis C virus (HCV) infection, HCV infection, and both negative (non-BC). The incident cases of HCC per quarter of the study period were 4311 (21.0%), 5505 (26.8%), 5776 (28.1%), and 4955 (24.1%), sequentially. Overall, 14,020 (68.2%) patients were male. The number of HCC cases in patients < 60 years, 60–69 years, 70–79 years, and ≥ 80 years were 3711 (18.1%), 6652 (32.4%), 7448 (36.2%), and 2736 (13.3%), respectively. The average age of newly-diagnosed patients increased in each quarter. HCC was associated with HBV, HBV + HCV, and HCV infections and non-BC in 2997 (14.6%), 187 (0.9%), and 12,019 (58.5%), and 5344 (26.0%) cases, respectively. The number of HCV-associated cases decreased in each quarter, while that of non-BC-associated cases increased. HCC incident cases tend to increase in the elderly and in non-BC patients; in contrast, HCC incident cases due to HCV tend to decrease., Scientific Reports, 12, art. no. 1517; 2022},
 title = {Trends in hepatocellular carcinoma incident cases in Japan between 1996 and 2019},
 volume = {12},
 year = {2022}
}