{"created":"2023-05-15T16:49:37.845360+00:00","id":27149,"links":{},"metadata":{"_buckets":{"deposit":"6ab90aa8-41b6-4348-9157-62cb4a8c19ac"},"_deposit":{"created_by":6,"id":"27149","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27149"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027149","sets":["10:11"]},"author_link":["121174","121171","121173","121172","121170","121175","121169"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"1269","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Medicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The ratio of free triiodothyronine (FT3) to free thyroxine (FT4) (FT3/FT4), a maker of peripheral thyroxin deiodination, could indicate activity of thyroid hormone. Since positive association between subclinical hypothyroidism (SCH) and chronic kidney disease (CKD) was reported, clarifying the association among FT3/FT4, SCH, and CKD could be an efficient tool to make a strategy for preventing CKD. A cross-sectional study with 1724 Japanese with normal thyroid hormone was conducted. Significant positive association between SCH and CKD was observed; the adjusted odds ratio (OR) and 95% confidence interval (95% CI) was 2.23 (1.38, 3.59). Even though, FT3/FT4 was found to be inversely associated with CKD whereas positively associated with SCH; the adjusted ORs and 95% CIs for 1 standard deviation (SD) increment of FT3/FT4 were 0.51 (0.35, 0.74) for CKD and 2.40 (1.34, 4.29) for SCH, respectively. FT3/FT4 was also found to be positively associated with SCH without CKD but not those with CKD; 1 SD increment of FT3/FT4 were 3.44 (1.72, 6.91) for SCH without CKD and 1.11 (0.40, 3.06) for SCH with CKD, respectively. Although further investigation is necessary, present study indicates that higher activity of peripheral thyroxin deiodination might have beneficial association on absence of CKD even among SCH which is positively associated with CKD.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Clinical Medicine, 11(5), art. no. 1269; 2022","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/jcm11051269","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2077-0383","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shin-Ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Noguchi, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamichi, Seiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashida, Naomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Takahiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-11"}],"displaytype":"detail","filename":"JCM11_1269.pdf","filesize":[{"value":"601.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCM11_1269.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27149/files/JCM11_1269.pdf"},"version_id":"d253b652-38ff-4bf7-bddc-e64d53d4a4b8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"triiodothyronine","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroxine","subitem_subject_scheme":"Other"},{"subitem_subject":"subclinical hypothyroidism","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic kidney disease","subitem_subject_scheme":"Other"},{"subitem_subject":"FT3/FT4","subitem_subject_scheme":"Other"},{"subitem_subject":"euthyroid","subitem_subject_scheme":"Other"},{"subitem_subject":"demand","subitem_subject_scheme":"Other"},{"subitem_subject":"prevent","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Associations among Ratio of Free Triiodothyronine to Free Thyroxine, Chronic Kidney Disease, and Subclinical Hypothyroidism","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Associations among Ratio of Free Triiodothyronine to Free Thyroxine, Chronic Kidney Disease, and Subclinical Hypothyroidism"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-11"},"publish_date":"2022-03-11","publish_status":"0","recid":"27149","relation_version_is_last":true,"title":["Associations among Ratio of Free Triiodothyronine to Free Thyroxine, Chronic Kidney Disease, and Subclinical Hypothyroidism"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:56:33.335352+00:00"}