@article{oai:nagasaki-u.repo.nii.ac.jp:00027249,
 author = {Torigoe, Kenta and Yamashita, Ayuko and Abe, Shinichi and Muta, Kumiko and Nishino, Tomoya},
 issue = {3},
 journal = {Toxins},
 month = {Mar},
 note = {A percutaneous renal biopsy is an essential tool for the diagnosis of various renal diseases;however, post-biopsy bleeding is a major complication. Hemocoagulase is a detoxified and purified snake venom enzyme that is widely used to prevent post-procedural bleeding. In this study, we retrospectively analyzed the effect of hemocoagulase on post-renal biopsy bleeding. We included 221 patients who underwent percutaneous renal biopsy between April 2017 and December 2020 and analyzed post-renal biopsy hemoglobin (Hb) decline in patients who were administered a periprocedural hemocoagulase injection. After the renal biopsy, the mean Hb decrease in the entire patient cohort was 0.33 ・ 0.84 g/dL. Periprocedural hemocoagulase injection lowered the Hb decline post-renal biopsy (0.50 ・ 0.87 vs. 0.23 ・ 0.80 g/dL, p = 0.0204). The propensity-matched cohort was also adjusted for factors influencing postprocedural bleeding; periprocedural hemocoagulase injection reduced the Hb decline post-renal biopsy (0.56 ・ 0.89 vs. 0.17 ・ 0.74 g/dL, p = 0.006). There were no adverse events (e.g., thrombosis and anaphylactic shock) due to hemocoagulase. Our study demonstrated the beneficial effect of hemocoagulase on post-renal biopsy Hb decline, suggesting its clinical value in preventing post-renal biopsy bleeding., Toxins, 14(3), art.no.223; 2022},
 title = {Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy},
 volume = {14},
 year = {2022}
}