{"created":"2023-05-15T16:49:45.464802+00:00","id":27343,"links":{},"metadata":{"_buckets":{"deposit":"601b7942-875a-4f58-ab89-133aa31cfb4a"},"_deposit":{"created_by":6,"id":"27343","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27343"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027343","sets":["10:11"]},"author_link":["121643","121662","121646","121648","121651","121654","121655","121664","121649","121658","121659","121665","121656","121650","121644","121657","121663","121666","121645","121660","121652","121647","121661","121653"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-04-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"116416","bibliographicVolumeNumber":"160","bibliographic_titles":[{"bibliographic_title":"Bone"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: The effects of daily teriparatide (20 μg) (D-PTH), weekly high-dose teriparatide (56.5 μg) (W-PTH), or bisphosphonates (BPs) on areal bone mineral density (aBMD), bone turnover markers (BTMs), volumetric BMD (vBMD), microarchitecture, and estimated strength were investigated in postmenopausal osteoporosis patients.\nMethods: The study participants were 131 women with a history of fragility fractures. They were randomized to receive D-PTH, W-PTH, or BPs (alendronate or risedronate) for 18 months. Dual-energy X-ray absorptiometry (DXA), BTMs, and high-resolution peripheral quantitative CT (HR-pQCT) parameters were evaluated at baseline and after 6 and 18 months of treatment. The primary endpoint was the change (%) in cortical thickness (Ct.Th) after 18 months' treatment compared with baseline.\nResults: DXA showed that D-PTH, W-PTH, and BPs increased lumbar spine aBMD (+12.0%, +8.5%, and +6.8%) and total hip aBMD (+3.0%, +2.1%, and +3.0%), but D-PTH and W-PTH decreased 1/3 radius aBMD (− 4.1%, − 3.0%, − 1.4%) after 18 months. On HR-pQCT, D-PTH increased trabecular vBMD (Tb.vBMD) at the distal radius and tibia after 18 months (+6.4%, +3.7%) compared with the BPs group, decreased cortical volumetric tissue mineral density (Ct.vTMD) (− 1.8%, − 0.9%) compared with the other groups, increased Ct.Th (+1.3%, +3.9%), and increased failure load (FL) (+4.7%, +4.4%). W-PTH increased Tb.vBMD (+5.3%, +1.9%), maintained Ct.vTMD (− 0.7%, +0.2%) compared with D-PTH, increased Ct.Th (+0.6%, +3.6%), and increased FL (+4.9%, +4.5%). The BPs increased Tb.vBMD only in the radius (+2.0%, +0.2%), maintained Ct.vTMD (− 0.6%, +0.3%), increased Ct.Th (+0.5%, +3.4%), and increased FL (+3.9%, +2.8%).\nConclusions: D-PTH and W-PTH comparably increased Ct.Th, the primary endpoint. D-PTH had a strong effect on trabecular bone. Although D-PTH decreased Ct.vTMD, it increased Ct.Th and total bone strength. W-PTH had a moderate effect on trabecular bone, maintained Ct.vTMD, and increased Ct.Th and total bone strength to the same extent as D-PTH.  ","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Bone, 160, art. no. 116416; 2022","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bone.2022.116416","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"87563282","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chiba, Ko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okazaki, Narihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurogi, Ayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Ai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Nobuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Adachi, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Era, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokota, Kazuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inoue, Takuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yabe, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furukawa, Keizo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Choko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuda, Keiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Shingo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Isobe, Yusaku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Satsuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morimoto, Shimpei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shuntaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Sawako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tashiro, Shigeki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yonekura, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osaki, Makoto"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-28"}],"displaytype":"detail","filename":"Bone160_116416.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Bone160_116416.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27343/files/Bone160_116416.pdf"},"version_id":"cb8327fb-b4de-48fc-aa04-94be95395da3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Teriparatide","subitem_subject_scheme":"Other"},{"subitem_subject":"Weekly teriparatide","subitem_subject_scheme":"Other"},{"subitem_subject":"High-dose teriparatide","subitem_subject_scheme":"Other"},{"subitem_subject":"High-resolution peripheral quantitative","subitem_subject_scheme":"Other"},{"subitem_subject":"computed tomography (HR-pQCT)","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone microarchite","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Randomized controlled trial of daily teriparatide, weekly high-dose teriparatide, or bisphosphonate in patients with postmenopausal osteoporosis: The TERABIT study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Randomized controlled trial of daily teriparatide, weekly high-dose teriparatide, or bisphosphonate in patients with postmenopausal osteoporosis: The TERABIT study"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-28"},"publish_date":"2022-04-28","publish_status":"0","recid":"27343","relation_version_is_last":true,"title":["Randomized controlled trial of daily teriparatide, weekly high-dose teriparatide, or bisphosphonate in patients with postmenopausal osteoporosis: The TERABIT study"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:51:06.925081+00:00"}