{"created":"2023-05-15T16:31:20.696060+00:00","id":2735,"links":{},"metadata":{"_buckets":{"deposit":"75463fbf-44b5-4cab-86e5-8f177742dd57"},"_deposit":{"created_by":2,"id":"2735","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2735"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002735","sets":["29:30:1713167819629:202"]},"author_link":["12606","12603","12599","12604","12600","12601","12605","12602"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"126","bibliographicPageStart":"117","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Gestational thrombocytopenia (GT) is detected in approximately 8% of healthy pregnant women and >70% of pregnancy-associated thrombocytopenia cases. Diagnosed by exclusion, GT is primarily a benign disorder of unclear pathogenesis, although mechanisms have been proposed such as hemodilution. To better understand GT, we conducted retrospective longitudinal and cross-sectional analyses of variations in platelet count (PC) during gestation period. \nMethods: PC kinetics was assessed across a test group of 100 pregnant women, accurately representative of 341 in total, and in a control group of 200 non-pregnant women. \nResults: In the test group, median PC was comparable to the control group in early gestation but decreased by 8% by delivery day (DD). PC decreased by >5% in 59 pregnancies and increased by >5% in 19. 12 cases were thrombocytopenic. Median PC fluctuation, 2.5th percentile, and 97.5th percentile were each most extreme in final 5 weeks. Longitudinal analysis established five gestational pattern types defined by curvature and Change Ratio. The GT-type pattern (8 cases) showed relatively low PC in early gestation, mild downwards slope in the 2nd trimester, one or more peaks or “lifts” in the final weeks, followed by a “V-shape” of decrease beyond 15 x 104/μL to DD and sharp post-partum increase. Some of the GT-associated characteristics above appeared identifiable in a majority of pregnancies regardless of absolute PC value: Distinct PC “lift” occurring within the final ten weeks [later than in GT cases] followed by the V-shape [decrease to DD less pronounced than in GT], suggesting that diverse PC kinetics relate to the placental cytokine and receptor system. \nConclusion: Our novel identification of diverse kinetic patterns in platelet count over gestational period suggests that, instead of a universal decrease caused by hemodilution alone, homeostatic conditions are affected by a diversity of varying factors such as the placental thrombopoietic system.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia, 61(3), pp.117-126; 2018","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagasaki University School of Medicine"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"05"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"長崎大学医学部"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kotera, Kohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamihira, Shimeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kerckhove, Charles de"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanematsu, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Kazuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Kiyonori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Hiroo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuzaki, Hideaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"ActMed61_117.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ActMed61_117.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2735/files/ActMed61_117.pdf"},"version_id":"4454ac42-9cd8-4948-ac74-46d684da3a4b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"platelet count","subitem_subject_scheme":"Other"},{"subitem_subject":"intra-individual variation","subitem_subject_scheme":"Other"},{"subitem_subject":"gestation","subitem_subject_scheme":"Other"},{"subitem_subject":"thrombocytopenia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A longitudinal, cross-sectional study of diversity in maternal platelet count kinetics, related to gestational thrombocytopenia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A longitudinal, cross-sectional study of diversity in maternal platelet count kinetics, related to gestational thrombocytopenia"}]},"item_type_id":"3","owner":"2","path":["202"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-14"},"publish_date":"2018-02-14","publish_status":"0","recid":"2735","relation_version_is_last":true,"title":["A longitudinal, cross-sectional study of diversity in maternal platelet count kinetics, related to gestational thrombocytopenia"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2024-04-16T05:26:16.635436+00:00"}