{"created":"2023-05-15T16:49:46.776903+00:00","id":27377,"links":{},"metadata":{"_buckets":{"deposit":"18fb979d-50f3-457c-8789-99939e433fb7"},"_deposit":{"created_by":6,"id":"27377","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27377"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027377","sets":["10:11"]},"author_link":["121808","121798","121801","121802","121795","121804","121805","121800","121794","121797","121806","121796","121799","121807","121803"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"420","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Biology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Boron neutron capture therapy (BNCT) is a non-invasive therapeutic technique for treating malignant tumors, however, methods to evaluate its therapeutic efficacy and adverse reactions are lacking. High mobility group box 1 (HMGB1) is an inflammatory molecule released during cell death. Therefore, we aimed to investigate HMGB1 as a biomarker for BNCT response, by examining the early responses of tumor cells to 10B-boronophenylalanine (BPA)-based BNCT in the Kyoto University Nuclear Reactor. Extracellular HMGB1 release was significantly increased in human squamous carcinoma SAS and melanoma A375 cells 24 h after neutron irradiation but not after γ-irradiation. At 3 days post-BPA-based BNCT irradiation in a SAS xenograft mouse model, plasma HMGB1 levels were higher than those in the non-irradiation control, and HMGB1 was detected in both nuclei and cytoplasm in tumor cells. Additionally, increased plasma HMGB1 levels post-BNCT irradiation were detected even when tumors decreased in size. Collectively, these results indicate that the extracellular HMGB1 release occurs at an early stage and is persistent when tumors are reduced in size; therefore, it is a potential biomarker for evaluating the therapeutic response during BNCT.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biology, 11(3), art. no. 420; 2022","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/biology11030420","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20797737","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imamichi, Shoji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chen, Lichao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Tasuku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tong, Ying"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onodera, Takae"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Yuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mauri, PierLuigi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sanada, Yu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Igaki, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Yasufumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itami, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masunaga, Shinichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masutani, Mitsuko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-13"}],"displaytype":"detail","filename":"Biology11_420.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Biology11_420.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27377/files/Biology11_420.pdf"},"version_id":"1ef19bb4-e96c-420d-adac-49e127770156"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"10B-boronophenylalanine (BPA)","subitem_subject_scheme":"Other"},{"subitem_subject":"boron neutron capture therapy (BNCT)","subitem_subject_scheme":"Other"},{"subitem_subject":"boron neutron capture reaction (BNCR)","subitem_subject_scheme":"Other"},{"subitem_subject":"high mobility group box 1 (HMGB1)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-13"},"publish_date":"2022-05-13","publish_status":"0","recid":"27377","relation_version_is_last":true,"title":["Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:48:24.103902+00:00"}