{"created":"2023-05-15T16:49:47.472578+00:00","id":27393,"links":{},"metadata":{"_buckets":{"deposit":"bd1cd335-33e6-4686-9d0f-63707852ecea"},"_deposit":{"created_by":6,"id":"27393","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27393"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027393","sets":["25:26"]},"author_link":["121861","121860","121862","121859"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-04-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5491038","bibliographicVolumeNumber":"2022","bibliographic_titles":[{"bibliographic_title":"Oxidative medicine and cellular longevity"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Atherosclerosis is the predominant cause of cardiovascular diseases. Existing studies suggest that the development of atherosclerosis is closely related to inflammation and immunity, but whether there are differences and similarities between atherosclerosis occurring at different sites is still unknown. We elucidated the pathological characteristics of peripheral vascular diseases by using bioinformatic analyses on immune cells and inflammation-related gene expression in atherosclerotic arteries and plaques. \nMethods: Eight data sets regarding atherosclerosis were downloaded from the Gene Expression Omnibus database. Human immune genes were obtained from the IMMPORT website. The samples were scored and divided into highand low-immune groups. Then the samples were analysed using weighted gene co-expression network analysis, while the modules were analysed using functional enrichment. The protein–protein interaction network was constructed using the STRING and Cytoscape databases. The hub immune genes were screened, and the correlation between hub immune genes and immune cells was analysed. \nResults: Immune cells and their functions were significantly different during atherosclerosis development. The infiltration proportion of immune cells was approximately similar in samples from different sources of patients with carotid atherosclerosis. However, the sensitivity of lower extremity atherosclerosis samples to immune cells is lower than that of carotid atherosclerosis samples.The samples from the plaque and artery were mainly infiltrated by macrophages, T cells and mast cells. After immune cells were assessed, resting NK cells, activated mast cells and M0 macrophages were found to be key immune cells in atherosclerosis and plaque formation. In addition, CCL4, TLR2, IL1B and PTPRC were considered to be immune marker genes in atherosclerosis development. \nConclusion: Bioinformatic data analysis confirms the essential role of immune cells in cardiovascular diseases, and also indicates some differences of immune and inflammation characteristics of atherosclerosis between carotid and lower extremity arteries.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Oxidative medicine and cellular longevity, 2022, art. no. 5491038; 2022　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1155/2022/5491038","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 HAN NIE et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"19420994","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NIE, HAN"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yan, Chen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhou, Weimin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Tao-sheng"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-17"}],"displaytype":"detail","filename":"OMCL2022_5491038.pdf","filesize":[{"value":"8.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"OMCL2022_5491038.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27393/files/OMCL2022_5491038.pdf"},"version_id":"5ac82ba0-4471-475c-96f3-7564ae15ecaf"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Analysis of Immune and Inflammation Characteristics of Atherosclerosis from Different Sample Sources","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of Immune and Inflammation Characteristics of Atherosclerosis from Different Sample Sources"}]},"item_type_id":"2","owner":"6","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-17"},"publish_date":"2022-05-17","publish_status":"0","recid":"27393","relation_version_is_last":true,"title":["Analysis of Immune and Inflammation Characteristics of Atherosclerosis from Different Sample Sources"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:47:11.516538+00:00"}