{"created":"2023-05-15T16:49:48.032553+00:00","id":27406,"links":{},"metadata":{"_buckets":{"deposit":"e29309df-524c-41bc-bfac-5304e1fc0bbc"},"_deposit":{"created_by":6,"id":"27406","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27406"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027406","sets":["10:11"]},"author_link":["121921","121918","121915","121916","121919","121917","121922","121925","121929","121923","121928","121927","121926","121924","121920"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-04-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"436","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Journal of Fungi"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) are important fungal infections caused by Aspergillus species. An overlap of ABPA and CPA has been reported; therefore, it is critical to determine whether the main pathology is ABPA or CPA and whether antifungals are required. In this study, we investigated whether the serum cytokine profile is useful for understanding the pathology and for differentiating between these diseases. We compared the various serum cytokine levels among healthy subjects and patients diagnosed with asthma, ABPA, or CPA at Nagasaki University Hospital between January 2003 and December 2018. In total, 14 healthy subjects, 19 patients with asthma, 11 with ABPA, and 10 with CPA were enrolled. Interleukin (IL) -5 levels were significantly higher in patients with ABPA than in those with CPA, and IL-33 and tumor necrosis factor (TNF) levels were significantly higher in patients with CPA than in those with asthma (p < 0.05, Dunn’s multiple comparison test). The sensitivity and specificity of the IL-10/IL-5 ratio (cutoff index 2.47) for diagnosing CPA were 70% and 100%, respectively. The serum cytokine profile is useful in understanding the pathology of ABPA and CPA, and the IL-10/IL-5 ratio may be a novel supplemental biomarker for indicating the pathology of CPA. ","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Fungi, 8(5), art. no. 436; 2022","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/jof8050436","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2309-608X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ito, Yuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takazono, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Obase, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukahori, Susumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ashizawa, Nobuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirayama, Tatsuro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tashiro, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Kazuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imamura, Yoshifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hosogaya, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushima, Chizu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morinaga, Yoshitomo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagihara, Katsunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumikawa, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mukae, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-24"}],"displaytype":"detail","filename":"JF8_436.pdf","filesize":[{"value":"889.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JF8_436.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27406/files/JF8_436.pdf"},"version_id":"0295ab4d-c1f6-4df0-98c4-bc6a9e34974f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"allergic bronchopulmonary aspergillosis","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic pulmonary aspergillosis","subitem_subject_scheme":"Other"},{"subitem_subject":"serum cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-33","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-10/IL-5","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-24"},"publish_date":"2022-05-24","publish_status":"0","recid":"27406","relation_version_is_last":true,"title":["Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:46:13.123943+00:00"}