@phdthesis{oai:nagasaki-u.repo.nii.ac.jp:00027437,
 author = {山根, 主信},
 month = {Mar},
 note = {Background: The effect of chronic sputum (CS) symptoms on health-related quality of life (HRQOL) in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has not been studied. The aim of this study was to clarify the differences in the clinical characteristics of NTM-PD patients with and without CS and to investigate the effect of CS on HRQOL.
Methods: This cross-sectional study included patients with NTM-PD who were prescribed pulmonary rehabilitation at the Fukujuji Hospital from March 2016 to June 2019. HRQOL was evaluated using the MOS 36-Item Short-Form Health Survey (SF-36).
Results: Of the 99 subjects studied, 71 had CS (CS+) (71.7%), and 28 (28.3%) did not have CS (CS-). Patients in the CS + group had a lower body mass index, forced vital capacity percent predicted, and forced expiratory volume in 1 s percent predicted. Regarding the radiological evaluation, the proportion of patients with the fibrocavitary form and the radiological score were significantly higher in the CS + group. The mental component summary (MCS) score of the SF-36 were significantly lower in the CS + group. Multiple regression analysis showed that the presence of CS was independently associated with a lower MCS score of the SF-36.
Conclusions: NTM-PD patients with CS had more severe disease, with reduced pulmonary function and severe radiological findings. CS was shown to independently affect HRQOL, especially mental status., 長崎大学学位論文 学位記番号:博(医歯薬)甲第1399号 学位授与年月日:令和4年3月31日, Author: Kazumasa Yamane, Koji Furuuchi, Mitsuru Tabusadani, Satoshi Takao, Yuki Kuroyama, Yusuke Matsumura,  Kosuke Mori, Kazuki Ono, Kazuma Kawahara, Shunya Omatsu, Yuki Toyoda, Keiji Fujiwara, Kozo Morimoto, Hideaki Senjyu, Citation: Respiratory Investigation, 60(2), pp. 277-283; 2022, Nagasaki University (長崎大学), 博士(医学) (2022-03-31)},
 school = {Nagasaki University (長崎大学)},
 title = {Influence of chronic sputum symptoms on quality of life in patients with nontuberculous mycobacterial pulmonary disease: a cross-sectional study},
 year = {2022}
}