{"created":"2023-05-15T16:49:50.892040+00:00","id":27471,"links":{},"metadata":{"_buckets":{"deposit":"027c3bc0-dd2c-49e6-975c-5ca894f08b03"},"_deposit":{"created_by":6,"id":"27471","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27471"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027471","sets":["10:11"]},"author_link":["122103","122095","122107","122105","122101","122096","122097","122104","122108","122106","122099","122098","122100","122102","122094"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageStart":"104604","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"iScience"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"SLITRK2 encodes a transmembrane protein that modulates neurite outgrowth and synaptic activities and is implicated in bipolar disorder. Here, we addressed its physiological roles in mice. In the brain, the Slitrk2 protein was strongly detected in the hippocampus, vestibulocerebellum, and precerebellar nuclei—the vestibular-cerebellar-brainstem neural network including pontine gray and tegmental reticular nucleus. Slitrk2 knockout (KO) mice exhibited increased locomotor activity in novel environments, antidepressant-like behaviors, enhanced vestibular function, and increased plasticity at mossy fiber–CA3 synapses with reduced sensitivity to serotonin. A serotonin metabolite was increased in the hippocampus and amygdala, and serotonergic neurons in the raphe nuclei were decreased in Slitrk2 KO mice. When KO mice were treated with methylphenidate, lithium, or fluoxetine, the mood stabilizer lithium showed a genotype-dependent effect. Taken together, Slitrk2 deficiency causes aberrant neural network activity, synaptic integrity, vestibular function, and serotonergic function, providing molecular-neurophysiological insight into the brain dysregulation in bipolar disorders.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"iScience, 25 (7), art. no. 104604; 2022　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.isci.2022.104604","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":" © 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"25890042","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Katayama, Kei-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morimura, Naoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Katsunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Corbett, Danielle"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Takehito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ornthanalai, Veravej G."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsunaga, Hayato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Wakako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Yoshifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akagi, Takumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashikawa, Tsutomu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Kazuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murphy, Niall P."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagao, Soichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aruga, Jun"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-12"}],"displaytype":"detail","filename":"IS25_104604.pdf","filesize":[{"value":"6.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IS25_104604.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27471/files/IS25_104604.pdf"},"version_id":"a8ef567f-0b85-4d08-a5f9-612334f751e2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-07-12"},"publish_date":"2022-07-12","publish_status":"0","recid":"27471","relation_version_is_last":true,"title":["Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:43:07.062554+00:00"}